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Pharma Drugs > Cholinergic Agonists > Flashcards

Cholinergic Agonists Flashcards

1
Q

Parasympathomimetics actions (Cholinergic)

A

Decreases heart rate & CO
Bronchoconstriction , Miosis
Increases GI tract motility +lacrimation + urination

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2
Q

Nicotinic Receptors Types

A

Muscular/NMJ (Nm) / Ganglionic (Nn)

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3
Q

Muscarinic Receptors Types

A

M1- Gq (neural , gastric), M2- Gi (cardiac), M3-Gq (glandular/smooth muscle),

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4
Q

Bethanechol Type

A

Direct Acting Cholinergic Agonist (not hydrolyzed by acetylcholinesterase)

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5
Q

Bethanechol Uses

A

Urinary Retention

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6
Q

Bethanechol MOA

A

increases bladder smooth muscle tone

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7
Q

Bethanechol Side Effects

A

generalized cholinergic stimulation

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8
Q

Carbachol

A

Direct Acting Cholinergic Agonist (not hydrolyzed by acetylcholinesterase)

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9
Q

Carbachol Uses

A

Glaucoma

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10
Q

Carbachol MOA.

A

miosis (Muscarinic & Nicotinic)

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11
Q

Pilocarpine

A

Direct Acting Cholinergic Agonist (not hydrolyzed by acetylcholinesterase)

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12
Q

Pilocarpine Uses

A

Glaucoma , Xerostomia

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13
Q

Pilocarpine MOA

A

miosis , inc. sweat , tears , & saliva (M. effect)

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14
Q

Methacholine

A

Direct Acting Cholinergic Agonist (doesn’t Cross BBB)

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15
Q

Methacholine MOA

A

Bronchoconstriction

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16
Q

Methacholine Uses

A

diagnose bronchial hypersensitivity (Methacholine Challenge Test)

17
Q

Physostigmine

A

Indirect acting cholinergic agonist (inhibits AchE)

18
Q

Physostigmine Uses

A

Glaucoma (not v effective) , Atropine/tricyclic AD overdoses , used to increase intestinal & bladder motility

19
Q

Physostigmine Side Effects

A

Convulsions , bradycardia , skeletal muscle paralysis (high doses)

20
Q

Neostigmine

A

Indirect acting cholinergic agonist (inhibits AchE)

21
Q

Neostigmine Uses

A

Treats Myasthenia Gravis (greater effect on Nm) , antidote for tubocurarine

22
Q

Edrophonium

A

Indirect acting cholinergic agonist (inhibits AchE)

23
Q

Edrophonium Uses

A

Diagnosis of MG

24
Q

Donepezil, Rivastigmine, Galantamine Uses

A

delay progression of Alzheimer’s

25
Q

Donepezil, Rivastigmine, Galantamine

A

Indirect acting cholinergic agonist (inhibit AchE)

26
Q

Nerve Gaz (sarin)

A

Indirect Acting Cholinergic Agonists: Irreversible

27
Q

Nerve Gaz Effects

A

Respiratory depression

28
Q

Echothiophate

A

Indirect Acting Cholinergic Agonists: Irreversible

29
Q

Echothiophate Uses

30
Q

Pralidoxime MOA

A

Reactivation of inhibited AChE

31
Q

Pralidoxime Uses

A

treat organophosphate and pesticide poisoning

32
Q

Ach Cardiovascular Actions

A

decreases HR : M2-R (inhibit AC & Ca entry) , Decreases BP : M3-R (nitric oxide= SM relaxation)

33
Q

Ach GI + Eye actions

A

Increases salivary secretion & motility
Contraction: colicky pain / expulsion of urine (Tone of muscle is increased) / miosis

34
Q

Ach Adverse Effects

A

Diarrhea , nausea , urinary urgency , miosis , diaphoresis

35
Q

Nicotine Actions

A

Low doses: stimulation of ganglionic nicotinic receptors → enhancing S (BV) and PS (heart+GI)
High doses: depolarizing blockade of ganglia

36
Q

Suxamethonium MOA

A

Depolarizing Nm blocker (agonist)

Pharma Drugs (11 decks)

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