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Pharma Drugs > Cholinergic Antagonists > Flashcards

Cholinergic Antagonists Flashcards

1
Q

Cholinergic Antagonists Types

A

Antimuscarinic / Ganglionic blockers / Neuromuscular blockers

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2
Q

Atropine

A

Competitive Antimuscarinic

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3
Q

Atropine Eye Actions

A

Mydriasis + Cycloplegia + unresponsiveness to light

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4
Q

Atropine Uses

A

Ophthalmic examinations , sinus bradycardia , urinary urgency/ enuresis , antidote for AchE poisoning

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5
Q

Atropine GI effects

A

Antispasmodic , antisecretory ( saliva , lacrimation , sweat) , decreases bladder hypermotility (urinary retention)

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6
Q

Atropine CVP effects

A

Tachycardia , bronchodilation (reduced secretions)

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7
Q

Atropine CNS effects

A

Excitatory , restlessness , irritability

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8
Q

Atropine Adverse Effects

A

urinary retention , mydriasis , constipation , xerostomia

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9
Q

Atropine CI

A

Glaucoma , prostate enlargement

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10
Q

Scopolamine

A

Oral Antimuscarinic

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11
Q

Scopolamine Uses

A

helps with motion sickness (sedation + dryness)

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12
Q

Ipratropium

A

Inhaler ; antimuscarinic

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13
Q

Ipratropium Uses

A

Asthma & COPD

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14
Q

Tropicamide

A

topical antimuscarinic

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15
Q

Tropicamide Uses

A

Mydriasis (short duration)

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16
Q

Nicotine, Hexamethonium, Tubocurarine

A

Ganglionic blockers ( Nn-R)

17
Q

Nicotine, Hexamethonium, Tubocurarine
MOA

A

Causes stimulation then paralysis of all ganglia

18
Q

Succinylcholine

A

Neuromuscular Blocking Drug - Depolarizing Agonist

19
Q

Succinylcholine MOA

A

Acts like Ach (longer action) ; depolarization , transient fasciculations , flaccid paralysis , repolarization , desensitized receptors.

20
Q

Succinylcholine Uses

A

Endotracheal intubation (muscle relaxation)

21
Q

Succinylcholine Adverse Effects

A

Hyperthermia (halothane) , apnea (AchE def.) , hyperkalemia (burn)

22
Q

Diazepam & Dantrolene

A

Neuromuscular Blocking Drugs (muscle relaxants)

23
Q

Tubocurarine/Pancuronium

A

Non-Depolarizing Antagonists (Competitive)

24
Q

Non-Depolarizing Antagonists MOA

A

Act on Nm to prevent binding of ACh : inhibit depolarization & contraction (use neostigmine to counteract this effect)

25
Q

Mivacurium, Atracurium

A

Non-Depolarizing Antagonists

26
Q

Mivacurium, Atracurium Adverse

A

release histamine = fall in BP , flushing , bronchoconstriction

27
Q

Non-Depolarizing Antagonists Uses

A

adjuvant in anesthesia during surgery , facilitate intubation

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