Adrenergic Antagonists

Question 1

Phenoxybenzamine

Answer 1

nonselective , noncompetitive irreversible alpha blocker ( more to a1)

Question 2

Phenoxybenzamine Uses

Answer 2

sweating & hypertension w/ pheochromocytoma , Raynaud’s

Question 3

Phenoxybenzamine Adverse

Answer 3

postural hypotension , reflex tachycardia (A2 blocked = NE release) , congestion , inhibit ejaculation

Question 4

Phentolamine

Answer 4

Nonselective competitive alpha blocker

Question 5

Phentolamine Uses

Answer 5

Pheochromocytoma management , post-NE extravasation dermal necrosis

Question 6

Prazosin

Answer 6

selective a1 competitive blocker (hypertension + BPH)

Question 7

Tamsulosin

Answer 7

selective a1a competitive blocker (BPH only)

Question 8

Alpha blockers caution

Answer 8

small doses before bed-time , not used as monotherapy

Question 9

Alpha blockers Adverse

Answer 9

lack of energy , congestion , floppy iris syndrome

Question 10

Beta blockers

Answer 10

All are competitive & selective at low doses only

Question 11

Propranolol

Answer 11

non selective B antagonist

Question 12

Propranolol Uses

Answer 12

Angina , Supraventricular cardiac arrhythmia , migraines , hyperthyroidism

Question 13

Nadolol & Timolol

Answer 13

nonselective B blocker / glaucoma ( decrease aqueous humor)

Question 14

Atenolol & Metoprolol

Answer 14

Selective B1 blockers (hypertension , angina , chronic heart failure)

Question 15

Acebutolol & Pindolol

Answer 15

antagonist w/ ISA ( weakly stimulate B1 (A) & B2 but don’t allow endogenous ligands to bind)

Question 16

Labetalol & Carvedilol

Answer 16

Antagonists for B & A