Protein Structure, Ligand Binding And Conformational Change- Reversible Binding And The Control Of Conformation Flashcards
What can the addition or removal of phosphate cause?
Reversible conformational change in proteins
What is a common form of post-translational modification?
The addition and removal of phosphate
What does the protein kinase do?
It catalyses the transfer of a phosphate group to other proteins
Where is the terminal phosphate of ATP is transferred to?
specific R groups
What does the protein phosphatases do?
It catalyses the removal of a phosphate group from other proteins
What does phosphorylation bring about?
Conformational changes which can affect a protein’s activity
What is regulated by phosphorylation of a protein?
The activity of many cellular proteins such as enzymes and receptors
Are some proteins activated by phosphorylation?
Yes but other are inhibited
Does adding a phosphate group add a positive or negative charge
A negative charge
Can ionic interactions in the unphosphorylated protein be disrupted?
Yes and new ones can be created
