Control Of programmed Cell Death (Apoptosis)

Question 1

What is apoptosis triggered by?

Answer 1

Cell death signals that can be external or internal

Question 2

What is an example of an external death signal?

Answer 2

The production of death signal molecules from lymphocytes

Question 3

What is an example of an internal death signal?

Answer 3

DNA damage

Question 4

What happens to the external death signals?

Answer 4

They bind to a surface receptor protein and trigger a protein cascade within the cytoplasm

Question 5

What is an internal death signal a result of?

Answer 5

DNA damage causing the activation of p53 tumour suppressor protein

Question 6

What do both internal and external death signals result in?

Answer 6

The activation of caspase (types of protease enzyme) that cause the destruction of the cell

Question 7

What is apoptosis essential during?

Answer 7

The development of an organism to remove cells no longer required as development progresses or during metamorphosis

Question 8

When might cells initiate apoptosis?

Answer 8

In the absence of growth factors