protein structure and sickle cell anemia

Question 1

Tags proteins to be destroyed

Answer 1

Ubiquaitan

Question 2

Results in sigmoid shape

Answer 2

cooperation binding

Question 3

Process made more likely by exercise/high alt/ dehydration

Answer 3

polymerization

Question 4

2 beta and 2 alpha chains

Answer 4

HbA

Question 5

2 gamma and 2 alpha chains

Answer 5

HbF

Question 6

Valine at pos 6

Answer 6

HbS (Sickle Cell Anemia)

Question 7

8 R alpha helix, single heme group

Answer 7

myoglobin

Question 8

2 alpha, 2 beta tetrahemic heme

Answer 8

hemoglobin

Question 9

The form amyloid fibers

Answer 9

PrPsc

Question 10

Defense Proteins

Answer 10

antibodies, snake venom, MHC proteins

Question 11

Catalysts proteins

Answer 11

preotease, polumerase, kinases

Question 12

Transport proteins

Answer 12

hemoglobin, myoglobin, cytochromes

Question 13

Support Protein

Answer 13

Collagen, Keratin, Fibrin

Question 14

Bonds between amino acids that generate primary sequence

Answer 14

Peptide bonds

Question 15

Mostly alpha helices and beta sheets

Answer 15

Secondary

Question 16

Compound heterozygous sickle cell disease

Answer 16

HbSC

Question 17

Altered ratio of alpha/beta globin

Answer 17

Thalassemias

Question 18

Sickle Cell Trait

Answer 18

HbSA

Question 19

2 alpha, 2 beta, S

Answer 19

HbSS - sickle cell diseae

Question 20

Point mutation converts this amino a. to valine at pos 6

Answer 20

Glutamate

Question 21

Build up of amyloid fibers cause this

Answer 21

prion disease

Question 22

Aspartate, Glutamate, Argine, Lysine, Histidine

Answer 22

Polar Charged AA

Question 23

Asparagine, Gltamine, Serine, Threonine

Answer 23

Polar uncharged AA

Question 24

Glycine, Alanine, Proline, Valine, Leucine, Isoleucine

Answer 24

Non-polar alphatic

Question 25

Phenylalanine, Tyrosine Tryptophan

Answer 25

Aromatic amino a.

Question 26

Methionine, Cysteine

Answer 26

Sulfur containing amino a.

Question 27

Transports O2 to mitochonidria

Answer 27

Myoglobin

Question 29

Soluble proteins must be coated in this type of amino a.

Answer 29

Polar

Question 30

Causes of denaturing

Answer 30

oxidative damage, pH change, temp. change

Question 31

carbohydrate addition modification

Answer 31

O or N - glycosylation

Question 32

Lipid addition modification

Answer 32

palmitoy, myristoy, prenylation

Question 33

prevent the aggregation of misfolded proteins

Answer 33

chaperone proteins

Question 34

Regulation modification

Answer 34

Phospory, acetylation

Question 35

mutations of protein alter

Answer 35

function, targeting, modifications, degradation, or have no effect

Question 36

glycosolation of hemeglobin causes this

Answer 36

diabetes

Question 37

Transports 02 from lungs to tissues

Answer 37

Hemeglobin