glycolysis Flashcards
Fx of glycolysis
to generate ATP
glucose products
Pyruvate, NADH and ATP
Get glucose into cell through these ports
GLUT 1-4 facilitated, GLUT 5 - symport
Glucose is transported with this molecule in the gut
Sodium
kd
disassociation constant, lower the number, more readily transported
When fasting liver will export or import glucose
export
glucose transporter used only in fed state
glut4
Entering pathway 1 glucose, 2 NAD+, 2 ADP , 2 Pi. Product?
2 pyruvate, 2 NADH, 2 ATP
anaerobic product of pyruvate breakdown
lactate - minimal ATP
aerobic product of pyruvate breakdown
pyruvate –> acetyl CoA - TCA cycle
cells that are only anaerobic
red blood cells, retina cells
Phases of glycolsis
preparative, atp generating
preperative phase energy use
2 ATP
glucose –> glucose 6 phosphate, enzyme, energy use?
hexokinase, 1 ATP
purpose of phosphorylation of glucose
trap in cell
2nd rx - glucose 6-phosphotase–> fructose 6-phosphate, energy use
phosphoglucomutase, 1 ATP
glucose 6-phosphate can go 3 places
glycolysis, glycogenogeosis, pentose phosphate
most important enzyme in glycolysis
phosphofructokinase-1 - PFK-1
fructose 6-phospate –> fructose 1,6 bis-phosphate, enzyme and energy use?
PFK-1, 2 ATP
cleaves fructose into 2 3 carbons chains
aldolase
fx of phospate dehydrogenase
adds phosphate to
fx of phosphoglyceratekinase
transfers a phosphate without oxygen
fx of phosphoglyceromutase
moves phosphate to central carbon
fx of enolase
removes water
