Prostaglandins And Other Eicosanoids

Question 0

LTC4 and LTD4

Answer 0

Bronchoconstrictiors important in anaphylaxis and cause edema

Question 1

LTB4

Answer 1

Chemotactic factor in inflammation

Question 2

Zileuton

Answer 2

Lox inhibitor - blocks synthesis asthma prophylaxis

Question 3

Montelukast zarfirlukast

Answer 3

Leukotriene receptor inhibitors

Blocks CydLT1 receptors reduces bronchoconstriction in asthma

Asthma prophylaxis

Question 4

TXA2

Answer 4

Causes platelet aggregation vasoconstriction

Question 5

Epoprostenol

Answer 5

PGI2 - causes vasodilation and reduces platelet aggregation

Used in pulmonary HTN and anti platelet agent in extra corporeal dialysis

Question 6

Misoprostol

Answer 6

PGE1 caused increased HCO3 and mucus secretion in stomach and uterine contraction

Protective agent in peptic ulcer disease
Abortifacient

Question 7

Alprostadil

Answer 7

Pge1

Injectable form for erectile dysfunction

Question 8

PGE1

Answer 8

Relaxes smooth muscle in ductus arteriosus

Transpositions of great vessels to maintain patent ductus until surgery

Question 9

Dinoprostone

Answer 9

PGE2
Low concentrations contract
Higher ones relax uterine and cervical smooth muscle

Used for abortions and cervical ripening

Question 10

Latanoprost

Answer 10

PGF2

Increases outflow of aqueous humor reduces intraocular pressure

Used in glaucoma

Color change in iris

Question 11

No selective cox1 and cox 2 inhibitors

Answer 11

Ibuprofen, indomethacin , naproxen

Reversibly inhibit both cox

Question 12

Aspirin

Answer 12

Irreversibly inhibit cox 1 and cox 2

Question 13

Celecoxib

Answer 13

Selectively reversibly inhibits cox 2

Question 14

PGI2

Answer 14

Prostacyclin formed by cox2 promotes vasodilation and inhibits platelet aggregation

Question 15

Acetaminophen

Answer 15

MOA: unclear may inhibit a cox3

Has analgesic effects and antipyretic . Lacks anti-inflammatory or anti platelet

Question 16

Ketorolac

Answer 16

Cox 1 selective

IM used for moderate to severe pain since it’s equal to morphine
Not an anti inflammatory
Short term use and not before surgery

Question 17

Flurbiprofen

Answer 17

Relatively cox 1 selective

Question 18

Ketoprofen

Answer 18

Non selective

Question 19

Aspirin

Answer 19

Non selective

Question 20

Naproxen

Answer 20

Non selective

Question 21

Ibuprofen

Answer 21

Non selective

Question 22

Indomethacin

Answer 22

Non selective

Question 23

Sulindac

Answer 23

Non selective

Question 24

Celecoxib

Answer 24

Relatively cox 2 selective

Question 25

Rofecoxib

Answer 25

Cox 2 selective withdrawn from market

Question 26

Valdecoxib

Answer 26

Cox 2 selective withdrawn from market

Question 27

What is the cv risk with cox 2 selective inhibitors

Answer 27

Cox-1 in platelets makes thromboxane which causes aggregation

Cox-2 makes prostacyclins PGI2 - which inhibits aggregation so if it’s blocked there is wayyyy too much TXA2 but not enough PGI2 and you get clots.

Naproxen has the least cv risk

Question 28

Tramadol

Answer 28

Not anti inflammatory
Not antipyretic
Is analgesic

Weak opioid agonist and inhibits NE and 5-HT uptake

Question 29

Acetaminophen toxicity

Answer 29

Metabolized by cyp450
Results in benzoquinone imminent hat normally reacts with glutathione to form non toxic metabolites. Large does deplete the glutathione and the metabolite reacts with sulfhydryl groups in hepatic proteins to cause necrosis