Bleeding Disorder - Pharm

Question 0

Aminocaproic acid : MOA , use , SE

Answer 0

MOA: inhibits plasminogen activation
Use: adjective therapy in hemophilia , bleeding from fibrinolytic therapy , prophylaxis for rebleeding from intracranial aneurysms
SE: intravascular thrombosis

don’t use in pts with DIC or genitourinary bleeding of the upper tract.

Question 1

Vitamin K

Answer 1

Vitamin K1 - oral and parental forms

• onset of effect is 6 hours
• effect is complete by 24 hours
• IV should be slow bc rapid infusion can cause dyspnea, chest and pain back and death

Question 2

Treatment of mild hemophilia for small bleeds - non blood product

Answer 2

Desmopressin acetate (DDAVP)

Question 3

Deep cuts or internal bleeding pt with hemophilia will be treated by

Answer 3

Replacing the missing clotting factor

Question 4

Factors VIII(a) and IX (b)

Answer 4

• derived from heat or detergent treated factor concentrates from large pools of plasma
• prions are not removed
  Best to use recombinant clotting factor preps
  -

Question 5

Recombinant IL- 11 that stimulates bone marrow platelet production

• used for patients with thrombocytopenia or prevention of it
• can causes anemia, fluid in the lungs and transient atrial arrhythmias

Answer 5

Oprelvekin

Question 6

Peptibody that contains an MpI binding peptide linked to FCC antibody fragment

• it activated thrombopoietin receptor

Answer 6

Romiplastin

Question 7

Use of romiplastin

Answer 7

Chronic idiopathic thrombocytopenia when a pt does not respond to steroid, Immunoglobulins or splenectomy

Question 8

Desmopressin

Answer 8

Analogue of vasopressin

- increases release of factor VIII and Von willebrand factor from storage sites

Question 9

Use of Desmopressin

Answer 9

Hemophilia A and vWF disease , used in prep for minor surgery like a tooth extraction

Can be used IV, SC, or intranasally