Antifungals Flashcards
Two names of polyenes
Nystatin ( topical)
Amphotericin
MOA of these drugs is to bind ergosterol in fungal cell membrane leading to cell death
Polyenes
Which candidia species is not sensitive to amB
C. lusitaniae ( lusitaniae sinks amB like the boat)
Other formulations of AmB .. Which one has the least Nephrotoxicity and infusion rxn
Liposomal Amphotericin b ) LAmB
The amp b colloidal dispersion is the worst and worst than the conventional AmB . The lipid complex is ok but lamb is better
This Azoles is used for onychomycosis
Itraconazole
Amphotericin toxicities and pk and pd
(Bind ergosterols in cell wall)
SE: Nephrotoxicity
Electrolyte wasting
Infusion related reactions
- poorly absorbed that’s why given IV , high distribution ( low in CNS) , concentration dependent
Inhibit fungal cytochrome p450 decreasing ergosterol formation
Azoles
What is the spectrum for amp b
Candidia, cryptococcus neoformans , dimorphic fungi and many molds
This Azoles doesn’t work against molds
Fluconazole
Inhibit beta 1,3-glucan synthase
Echinocandins
Azoles effective against ASPERGILLUS
Itraconazole , voriconazole
What is flu console ineffective against
C. Glabrata, c. Krusei, ( glide and cruise past fluconazole) aspergillus and molds
What is the big issue with Azoles
Drug interactions
What Azoles can you use for fungal UTIs
Fluconazole - excreted renally
Adverse reactions with Azoles
Hepatoxicity , rash and drug interactions
This Azole can be used to treat aspergillus, dematiaceous molds and dimorphic fungi
Itraconazole
Name the 5 major Azoles
Fluconazole, itraconazole,voriconazole , posaconazole, ketoconazole
Azoles are fungicidal to what and fungi static to
Fungicidal to molds and fungistatic to yeast . They are time dependent