Hypertension

Question 0

Captopril

Answer 0

Class 1 ACEi (active prior to metabolism)

Question 1

Aliskiren

Answer 1

Renin inhibitor, poor bioavailibilty

Contraindicated with ACEi and ARB in pt with diabetes

Question 2

Losartran

Answer 2

ARB

Question 3

Valsartan

Answer 3

ARB

Question 4

Verapamil and Diltiazam

Answer 4

CCB; - chronotroph, - ionotroph

Question 5

Nifedipine, amlodipine, felodipine

Answer 5

Dihydropyridines

Question 6

CCB Major Indication

Answer 6

Stable angina, Unstable angina (verapamil and diltiazem), hypertension, supraventricular tachycaridia (verapamil and diltiazem)

Question 7

Lisinopril

Answer 7

Class III ACEi: not metabolized and excreted unchanged

Question 8

ACEi indication

Answer 8

Hypertension; CHF; diabetic nephropathy; Post-myocardial infarct; type II diabetes

Question 9

ACEi Adverse Events

Answer 9

Dry cough/Skin Rash; hypotension; hyperkalemia (caution w/ pt. taking K sparing diuretics); acute renal failure due to dec GFR; teratogenesis; angioedema; neutropenia (Captopril); loss of taste (captopril); oral lesions (Captopril)

Question 10

amiloride/triamterene

Answer 10

K sparking diuretic, inhibit ENaC in collecting duct. (weak)

Question 11

Spironolactone/eplerenone

Answer 11

antagonize the effects of aldosterone at collecting duct

Question 12

conivaptan

Answer 12

Aquertic: Mixed V1 V2 antagonist delivered through IV (prevents transfer of aquaporin-2 onto collecting duct) Treatment for hyponatremia

Question 13

Tolivaptan

Answer 13

Aquaertic: oral V2 antagonist: treatment for hyponatremia

Question 14

Minoxidil

Answer 14

K channel opener, Rogaine