Problems Of Urinary Function: Acute Kidney Injury & Chronic Kidney Disease Flashcards
What is renal failure?
Happens when the kidneys cannot remove wastes or perform regulatory functions
What is acute renal failure?
reversible syndrome that results in decreased glomerular filtration rate(GFR) and oliguria lasts less than 3 months
What is chronic renal failure?
progressive; irreversible deterioration of renal function results in azotemia prognosis fatal- renal replacement therapies
dialysis, transplantation
What are the three causes of renal failure?
- pre-renal
- intrarenal
- postrenal
What is the cause pre renal in renal failure?
sudden and severe drop in blood pressure(shock) or interruption of blood flow to the kidneys from severe injury or illness
- impaired blood leak to hypoperfusion of the kidney and a drop in the GFR: hemorrhage, renal losses(diuretics, osmotic diuresis)
- impaired cardiac efficiency resulting from MI, heart failure, dysrhythmias, cardiogenic shock
- vasodilation resulting from sepsis, anaphylaxis, antihypertensive meds (or vasodilation drugs)
What is the cause intrarenal in renal failure?
direct damage to the kidneys by inflammation, toxins, drugs, infections, or reduced blood supply
prolonged renal ischemia, nephrotoxic agents, infectious processes
What is the cause postrenal in renal failure?
sudden obstruction of urine flow due to enlarged prostate, kidney stones, bladder tutor or injury
urinary tract obstruction: calculi, tumours, benign prostatic hyperplasia, strictures, blood clots
What is the cause of acute renal failure?
-obstruction of the kindness or lower urinary tract
- obstruction of renal arteries or veins
- Hypovolemia and hypotension
- reduced cardiac output and heart failure
What is the cause of chronic renal failure?
- ** DM and HTN**
- infections –> pyelonephritis
- obstruction of urinary tract
- heredity lesions
- vascular disorders
- meds or toxic agents
- chronic glomerulonephritis
What is acute kidney injury?
- varying and subtle degrees of renal impairment
- changes in first 48 hours
- 50% of cases have normal or increased urinary output
What is the etiology and pathophysiology of acute renal failure?
etiology: complex disorder, elevation in serum creatinine and anuric renal failure
pathological: hypovolemia and decreased renal blood flow, ischemia, tubules damages, edema and necrosis, globular filtrate leaks decreasing nitratubular fluid flow
What is the four phases of acute renal failure?
- onset
- oliguric-anuric
- diuretic
- recovery
What is the onset phase in acute renal failure?
- can last several hours or days
- gradual accumulation of nitrogen waste
- oliguria
What is the oliguric-anuric phase in acute renal failure?
-rise in urea, creatinine, uric acid, organic acid, and intracellular anions (potassium and magnesium)
- decreased urinary output
- decreased renal function but excrete normal urine amount
- metabolic acidosis
What is the diuretic phase in acute renal failure?
- gradually increase urine output
- glomerular filtration has started to recovery
-lab values stop rising and start dropping - renal function abnormal
- observe pt for dehydration
What is the recovery phase in acute renal failure?
- ct begins to return to normal levels of activity decrease energy level
- renal function may never return to preillnesss levels
- renal function is sufficient for a long healthy life
What is the collaborative care for acute renal failure?
- fluid restriction, nutritional therapy, enteral nutrition, and dialysis if indicated
- detailed treatment of hyperkalemia
primary goal: to eliminate cause, manage symptoms, and prevent complications
What is age related considerations for acute renal failure?
- more susceptible due to # of functioning neurons decrease with age
- impairment of other organ systems can increase risk of developing an AKI
- aging kidney less able to compensate for changes in fluid volume, soul load and cardiac output
- mortality rate higher
What is chronic kidney disease?
progressive, irreversible loss of kidney function
What is normal GFR?
GFR 125 ml/min
What is kidney failure GFR?
GFR <15ml/min
What is the two leading causes of end stage renal disease(ESRD)?
DM and HTN
What is the clinical manifestations for chronic kidney disease?
psychological changes,
effects all bodily systems
What is the accumulated waste products in CKD?
increased BUN and creatinine
What is metabolic disturbances in clinical manifestations for CKD?
defective carb metabolism caused by impaired glucose
- elevated triglycerides