Pro-coagulants and anti-anemics

Question 1

Procoagulants

Answer 1

Vitamin K1 (Phylloquinone)
Lyophilized factor 8
Desmpressin acetate
Factor 9
Fibrinogen cryoprecipitate

Question 2

Vitamin K1 -MOA

Answer 2

Matures factors 2, 7, 9, 10

Question 3

Vit K1 - adverse effects

Answer 3

Rapid administration > dyspnea, chest, back pain. Death

Question 4

Lyo Factor 8, Desmopressin acetate

Answer 4

Used for Hemophilia A (8 deficiency)

Question 5

Factor 9

Answer 5

Used for Hemophilia B (9 def)

Question 6

Fibrinogen Cyroprecipitate

Answer 6

Fibrinogen deficiency

Question 7

Anti-anemics - Iron

Answer 7

Oral (ferrous sulfate, gluconate, fumarate)
Parenteral (ferric gluconate, Iron sucrose)
IV/IM- Iron dextran

Question 8

Anti-anemics - B12

Answer 8

Cyanocobalamin (IM)

Hydroxocobalamin (IM)

Question 9

Anti-anemics - folate

Answer 9

Folate (oral)
Folinic acid (supplemented in cancer therapy)

Question 10

Anti-anemics - EPO

Answer 10

Stimulate RBC maturation

Question 11

Iron antidote (thalassemia)

Answer 11

Deferoxamine

Question 12

Sickle Cell treatment

Answer 12

Folate (lifetime)

Hydroxyurea (reactivates fetal Hb)

Question 13

Iron replacement - adverse effects

Answer 13

Nausea, heartburn, epigastric discomfort, abdominal cramps, constipation, diarrhea, necrotizing enterocolitis