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Pharm Block 2 > Arthritis drugs > Flashcards

Arthritis drugs Flashcards

1
Q

Symptomatic treatment of osteoarthritis

A

NSAIDS and Acetaminophen
Corticosteroids
Opioids

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2
Q

Drugs for Rheumatoid arthritis

A 
NSAIDS and Cox2's
Analgesics
Glucocorticoids
Disease-modifyng anti-rheumatic drugs (DMARDs)
Biologic response modifiers (BRMs)
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3
Q

DMARDs (prevent progression)

A

Hydrochloroquine
Sulfasalazine
Methotrexate
Leflunomide

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4
Q

Hydrochloroquine - MoA

A

unclear

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5
Q

HCQ - adverse effects

A

GI, skin, CNS

Blindness***

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6
Q

HCQ - indication

A

Mild RA

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7
Q

Sulfasalazine - MoA

A

gut bacteria reduce drug to sulfapyridine, then mechanism is unclear

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8
Q

Sulfasalazine - adverse

A

Hypersensitivity (rash, pneumonitis, hepatitis, agranulocytosis, aplastic anemia)**These always recur

Dose-related (GI, CNS, mild leukopenia)

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9
Q

Methotrexate - MoA

A

inhibits folate metabolism, then mechanism is unknown

“halts” disease progression

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10
Q

Methotrexate - adverse rxns

A

Stomatitis, alopecia, GI, CNS, macrocytosis (folate def)

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11
Q

Methotrexate - serious rxns

A

bone marrow suppression, hepatic fibrosis, liver failure, pulmonary fibrosis, lung failure

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12
Q

Leflunomide - MoA

A

converted to teriflunomide, then inhibits mitochondrial DHODH to block synthesis of rUMP

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13
Q

Leflunomide - adverse rxns

A 
neuropathy
diarrhea, nausea
hypertension
hepatitis, liver failure
leukopenia
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14
Q

Biological Response Modifiers

A 
Anti-cytokine therapies
   Anti-TNF
   Anti-IL-6
Costimulation blockade (t-cells)
B Cell depletion
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15
Q

Anti-TNFa drugs

A 
Etanercept
Infliximab
Adalimumab
Golimumab
Certolizumab
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16
Q

Etanercept - MoA

A

solubleTNFa receptor fusion protein

It’s a TNFa receptor attached to an IgG Fc domain

17
Q

Infliximab - MoA

A

chimeric (mouse) anti-TNFa IgG antibody

18
Q

Adalimumab, golimumab, certolizumab - MoA

A

human anti-TNFa

certo- is pegylated to increase half life

19
Q

Tocilizumab - MoA

A

anti-IL-6 receptor antibody and binds both soluble and membrane bound receptors

20
Q

Abatacept - MoA

A

co-stimulation blockage

CTLA-4 antigen attached to IgG Fc

Binds to CD80/86 (B7) on APC and produces anergic T-cells

21
Q

Abatacept - contraindications

A

do not use with TNF inhibitors (complete immunosuppression)

22
Q

Rituximab - MoA

A

Binds to and depletes all cells that are CD20+ (B-cells)

23
Q

Biological response modifiers - adverse effects

A

Activation of latent infections (TB, histo, hepB) - anti-TNFa’s
Hepatotoxicity
Demyelinating disorders

Pharm Block 2 (13 decks)

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