NSAIDS and Acetaminophen

Question 1

NSAIDS

Answer 1

Salicylates
Arylpropionic acid derivs
Arylacetic acid derivs
Oxicam derivs
Selective Cox-2's

Question 2

Salicylates

Answer 2

Aspirin

Diflunisal

Question 3

Arylpropionic acid derivs

Answer 3

Ibuprofen
Naproxen
Flurbiprofen
Ketoprofen
Oxaprozin

Question 4

Arylacetic acid derivs

Answer 4

Indomethacin
Sulindac
Diclofenac
Bromfenac
Ketorolac
Nabumetone
Etodolac

Question 5

Oxicam derivs

Answer 5

Piroxicam

Meloxicam

Question 6

Cox-2 inhibs

Answer 6

Celecoxib
Rofecoxib
Valdecoxib
Etoricoxib
Lumiracoxib

Question 7

Salicylates- adverse effects

Answer 7

1) Salicylism - mild intox. with headache, dizziness, tinnitus, hearing and vision impairment
2) Gastric Irritation (PGE2 inhib)
3) Hemorrhage
4) electrolyte imbalance
5) edema and acute renal failure
6) hyperthermia
7) hepatic toxicity
8) hyperuremia

Question 8

Other NSAIDs- adverse effects

Answer 8

1) Gastric irritation
2) GI microbleeding
3) Fluid retention
4) Renal failure
5) Rashes (naproxen)
6) Hepatotoxicity (bromfenac)

Question 9

NSAID hypersensitivity

Answer 9

1) Asthmatic attacks

2) Urticaria and angioedema

Question 10

NSAID drug interactions

Answer 10

1) increase warfarin effects by competing for albumin
2) blunt diuretic effects
3) enhance methotrexate toxicity by blocking tubular secretion
4) boost Lithium levels
5) blunt anti-hypertensive effects

Question 11

Acetaminophen - MoA

Answer 11

unknown - maybe Cox-3

Question 12

Acetaminophen overdose

Answer 12

nausea/vom, anorexia, abdominal pain.
Hepatotoxicity after 12 hours
Jaundice in 2-4 days

N-acetylcysteine increases glutathione production to reverse toxic effects