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Pharm Block 2 > Anti-lipidemic > Flashcards

Anti-lipidemic Flashcards

1
Q

Safe Ranges for Lipids

A

Total Cholesterol (

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2
Q

Anti-lipidemics (5)

A 
Resins
Statins
Niacin
Fibrates
Ezetimibe
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3
Q

Anion-exchange Resins (3)

A

Cholestyramine
Colestipol
Colesevelam

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4
Q

Resins - MoA

A

Sequester bile acids in the gut and block lipid emulsification

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5
Q

Resins - adverse effects

A

Bitter taste, nausea, constipation, incr. TG levels (irony)

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6
Q

Resins - drug interactions

A

binds polar drugs like warfarin, digoxin, thyroxine, and statins

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7
Q

Statins

A

-statin

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8
Q

Statins - MoA

A

blocks HMG-coA reductase and drops cholesterol levels

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9
Q

Statins- adverse effects

A

Hepatitis and myositis (rhabdo)

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10
Q

Rhabdomyolysis risks

A

Taking fibrates, nicotinic acid, HAART therapy

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11
Q

Nicotinic Acid (Niacin) - MoA

A

Decr. Hepatic VLDL synthesis by inhibiting adipose lipolysis

Incr. VLDL clearance by incr LPL activity

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12
Q

Nicotinic acid - happy side effect

A

boosts HDL by 30-50%

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13
Q

Nicotinic acid - adverse effects

A

Flushing (prostaglandin)
Skin dryness
GI intolerance
Incr Gout, diabetes, and ulcers

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14
Q

Fibrates - MoA

A

PPARa ligands
Incr ApoA and incr HDL
Incr LPL activity
Incr fatty acid uptake into muscle cells and hepatocytes

Drops VLDL and triglycerides

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15
Q

Fibrates - adverse effects

A

GI intolerance
Gall stones
Myopathy
Displace Warfarin

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16
Q

Ezetimibe - MoA

A

Inhibits intestinal cholesterol transporter

Pharm Block 2 (13 decks)

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