principles of neuroscience Flashcards
first account of brain
ancient egypt
what is dualism?
plato
body and soul
soul = essemtial
three parts, reason emotion and desire
what is aristotles view of the soul
monism
3 divisions
soul in heart
brain cools blood bc heart first to develop
hippocrates
materialism - the brain is the only cause of our behaviour, injuries to one side of the brain lead to damage on the other side of the body. Diseases have natural causes rather than being cause by Gods.
roman period
galen
4 humours
nevres filled with humours since they connected to all different parts of body
da vinici anatomical drawing
three ventrcles in brain holding humours
common sense, thinking and memory
descartes
substance dualism
pineal gland = valve that controls flow of liquid into body , this is our mind
West riding pauper lunatic asylum
John hughlings Jackson - seizures that affected left side of brain result in change in the right side of the body.
Willis
father of neursoecience terms such as ceberal cortex, localistaion of cuntion, less education from galen so new view of brain
franz gall
phrenology - bumps on head - measured and assigned to a behaviour trait
Essentially localisation of function - flawed brain is too soft to influence the structure of the skull - not a favourable study
Fluorenes
equipotentiality - brain = holistic, size of lesion more important than where
Broca’s area
frontal lobe, speech production, if damaged laborious slow speech, as found in his patient ‘Tan’ who could only say tan, found abnormalities in his brain during post-mortem examination.
Wernicke’s area
speech comprehension, meaningless speech if damaged
Phineas gage
nice guy, injured frontal lobe, completely changed
what advancements in technology FIRST improved our understanding of structure of the brain
microscope
microtome
stains
Glolgi
developed reliable stain of brain showing neural pathways
proof of synapses
sherrington using electron microscope
brodmann and localisation
different because they have differemt architecture
Galvani and electrical communication
frog legs suspended from a wire moved when lightning struck
what happened when japanese actore are liver of puffer fish
he died because their poison prevents the transmission of action potentials, couldnt move diaghram so died.
what are the three potentials of a neuron
resting action potential and graded
how does a neuron maintain its resting state?
resting state = -70mV
there are ions in and outside of the cell membrane
there are more sodium out of the cell and pottasium inside of the cell due to gradients and electrical gradient this stays that way.
there are ion pumps and ion channels that control movement of ions in the membrane.,
sodium-pottasium pump pumps out 3 sodium ions and takes in 2 potasium ions. more.
what is in the cell membrane
leaky channels = free flowing (sodium and pottasium)
voltage gated pump - sodium potassium pump - lets two K in and Na three out