principles of endocrinology Flashcards
hormone synthesis: recall the principle stages of protein and steroid hormone synthesis, storage, and mechanism of secretion
1
Q
how are protein/polypeptide hormones synthesised: pro-hormone to hormone
A
pro-hormone packaged into vesicle; transported to Golgi apparatus where processed by proteolytic enzymes; broken down to mature active hormone; wait until signal for exocytosis (regulated secretion)
2
Q
how fast are peptide hormones broken down and cleared from the blood stream
A
relatively fast
3
Q
which blood vessels are pituitary hormones secreted into
A
pituitary capillary
4
Q
how are steroid hormones synthesised: cholesterol liberation to mitochondria
A
esterase liberates cholesterol from fatty acid esters within adrenal gland cells; taken into mitochondria by StAR protein (rate limiting step)
5
Q
why are steroid hormones not stored in cells
A
too lipid soluble, hence stored in bloodstream
