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LCRS Endocrinology > adrenals > Flashcards

adrenals Flashcards

hypothalamo-pituitary-adrenal axis: explain the hypothalamo-pituitary-adrenal axis for cortisol release and regulation

1
Q

hypothalamo-pituitary-adrenal axis

A

CRH (corticotropin releasing hormone) in hypothalamus → ACTH (adrenocorticotropic hormone) in anterior pituitary → cortisol in adrenal → direct (pituitary) and indirect (glucocorticoid receptors in hypothalamus) negative feedback

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2
Q

what influences hypothalamo-pituitary-adrenal axis

A

caffeine (increases cortisol production) and alcohol (decreases cortisol production)

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3
Q

ACTH precursor

A

POMC (pro-opio-melanocortin)

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4
Q

what peptides is POMC cleaved into

A

ACTH, MSH and endorphins

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5
Q

clincial signs of high POMC levels

A

excess MSH production (production and release of melanin) so pigmentation in many areas (skin, mouth, scars)

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LCRS Endocrinology (34 decks)

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