Primary Sclerosing Cholangitis Flashcards
1
Q
What is the pathophysiology of PSC?
A
Inflammation and fibrosis of intra & extra hepatic bile ducts
2
Q
What conditions are associated with PSC?
A
- Ulcerative colitis: 80% of patients with PSC have UC.
- Crohn’s (Much less common)
- HIV
3
Q
What are the features of PSC?
A
- Cholestasis: jaundice and pruritus
- Right upper quadrant pain
- Fatigue
4
Q
What is the diagnostic test fcor PSC?
A
ERCP - shows multiple biliary strictures
5
Q
What autoantibody may be positive in PSC?
A
ANCA
6
Q
What are some complications of PSC?
A
- Cholangiocarcinoma
- Increased risk of colorectal cancer
