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Gastroenterology > Autoimmune Hepatitis > Flashcards

Autoimmune Hepatitis Flashcards

1
Q

What gender is autoimmune hepatitis more commonly seen in?

A

Female

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2
Q

What are some features of autoimmune hepatitis?

A
  • Amenorrhoea (common)May present with signs of chronic liver disease
  • Acute hepatitis: fever, jaundice etc (only 25% present in this way)
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3
Q

What autoantibodies and Ig can you test for that might be positive?

A
  • ANA
  • SMA (Anti-smooth muscle antibody)
  • LKM1
  • Raised IgG levels
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4
Q

To diagnose, a liver biopsy is often needed. What can be seen on biopsy?

A

Liver biopsy: inflammation extending beyond limiting plate ‘piecemeal necrosis’, bridging necrosis

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5
Q

Describe the 3 different types of autoimmune hepatitis.

A

Type 1 - ANA +/- SMA will be present. Affects child and adults.

Type 2 - LKM1 antibodies -affects children only

Type 3 - Soluble liver kidney antigen. Affects middle aged adults.

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6
Q

How is autoimmune hepatitis managed?

A
  • Steroids
  • Immunosuppresants.
  • Liver transplanation
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Gastroenterology (25 decks)

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