Primary biliary cholangitis Flashcards
1
Q
Cause
A
Destruction of small intrahepatic bile ducts due to anti-microbial antibodies
2
Q
What is cholestasis
A
Flow of bile from liver to bile ducts is obstructed
3
Q
Consequences of cholestasis
A
Inflammation to hepatocytes, leading to fibrosis, cirrohosis and liver fialure
4
Q
Symptoms of PBC
A
Pruritis Jaundice RUQ Autonomic dysfunction e.g. postural dizziness, loss of concentration, dry eyes and dry mouth (sjogren's) Symptoms of cirrhosis/liver failure
5
Q
Rx
A
PMH of autoimmune disease FH of autoimmune disease Smoking Hypercholestrolemia UTIs
6
Q
What is a key risk factor and for which population?
A
UTIs
Caucasians
7
Q
Epidemiology of PBC
A
Middle aged young women (UTI also common in this group)
