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Year 3 - Gastro > Autoimmune hepatitis > Flashcards

Autoimmune hepatitis Flashcards

1
Q

What would you screen for if suspecting AIH?

A

Serum immunoglobulins
ANA
SMA
Anti-LKM1

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2
Q

Which of these is not always positive?

A

SMA

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3
Q

What investigation is done to confirm diagnosis? What does this tell you and why is it important?

A

Liver biopsy - tells you which cells have infiltrated, can be prognostic marker

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4
Q

What might be seen on histology of AIH liver?

A 
Plasma cell localisation 
Submassive necrosis (26-75%)
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5
Q

Treatment

A

Prednisolone 30mg
Azathioprine

(steroid + immunosuppressant)

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6
Q

Epidemiology

A

Mainly women

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7
Q

Define

A

Chronic inflammatory disease of the liver of unknown aetiology, characterised by the presence of circulating auto-antibodies with a high serum globulin concentration, inflammatory changes on liver histology, and a favourable response to immunosuppressive treatment

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8
Q

Prognosis

A

Relapse common
10% require transplant
Increase risk of hepatocellular carcinoma

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Year 3 - Gastro (42 decks)

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