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Pharma2023 > Prelimnary > Flashcards

Prelimnary Flashcards

1
Q

What do you do when there is impaired drug metabolism?

A

Reduce doors in several of impairment, reduce stores in elderly patients. There is a reduction in liver, volume, reduce metabolism of liposomal drugs, important for an hour therapeutic drugs.

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2
Q

Hyponatraemia

A

Reduce protein binding increase Friedrich, concentration of highly protein, bound drugs, toxicity

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3
Q

Reduced bile excretion

A

Fusidic acid rifampicin excreted in bile can accumulate

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4
Q

Hepatic encephalopathy

A

In severe, liver, disease drugs can impair cerebral function and can precipitate, a hepatic coma , such as constipating drugs are dating drugs, and drugs that cause hypokalaemia

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5
Q

How is hepatic encephalopathy treated?

A

Lactulose

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6
Q

Odema and ascites in liver disease can be exacerbated by

A

Drugs which cause fluid retention nsaid and corticosteroids

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7
Q

Enzyme inhibitors

A

Sickfaces.com
Sodium valproate
Isoniazid
Cimetidine
Ketoconazole
Flucanzole
Alcohol
Chlorphenicol
Erythromycin
Sulphonamide
Ciporfloxaxin
Omepraze
Metronidazole

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8
Q

Enzyme inducers

A

Barbiturates
St johns wort
Carbamazepine
RifMipicn
Alchol
Phenytoin
Griseofulvin
Phenobarbital
Sulfonyureas

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9
Q

Enzyme inhibitors =

A

Increased plasma concentration

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10
Q

Drugs which interact with grapefruit juice

A

Amiodarone ranoazine verapmail quetiapine sertaline taxrolimus ciclosporin colchine sildenfil

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11
Q

Which drugs should be stopped temporarily during any in the state which can result in dehydration

A

Damn
Diuretics
Ace inhibitors
Metformin
Nsaids

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12
Q

Breakthrough pain for immediate release morphine

A

1/6 to 1/10th of daily dose

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13
Q

Excess respiratory secretions for palliative care

A

Hyoscine or glycopyrru

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14
Q

Bowel colic in palliative care

A

Loperamide

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15
Q

Side effects ratio meaning

A

1 in 10 = very common
1 in 100 common
1 in 1000 uncommon
1 in 10,000 rare
1 in 10,000 very rare

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16
Q

Which drugs cause oral ulcers

A

Ace inhibitor
Nsaids
Nicrorandil
Methotrexate

17
Q

Which drugs cause Oral candidiasis

A

Corticosteroids inhalers

18
Q

Staining of teeth

A

Chlorhexidine iron tetracycline

19
Q

Which drugs cause ostenocrosis of the jaw

A

Bisphosphantes

20
Q

Which drugs cause ginivi hypertrophy

A

Ciclosporin nifedipine phenytoin

21
Q

Which drugs cause Taste disurbances

A

Metformin ace inhibitor Amiodarone carbimazole claithryomycin metformin metronidazole zoplicone

22
Q

Which two drugs do not chase myelosuppresipn

A

Vincristine and belomycin

23
Q

Which drugs cause contact sensitisation

A

Methotrexate chlorpromazine cytotoxic drugs

24
Q

Predisposing factors for QT prolongnation

A

Increase age female sex cardiac disease bradycardia electrolyte disturbance hypokalemia hypomangesia Hypocalcemia

25
Q

Drugs which cause peripheral neuropathy

A

Amiodarone cisplatin phenytoin isoniazid metronidazole Vila alkaloids

26
Q

Which drugs cause serotonin. Syndrome

A

Sumatriptan bupropion buspirone antidepressant mao-b

27
Q

What do sugar free preparation mean

A

Do not contain fructose sucrose glucose

28
Q

Is benzoyl alchol recommended in neonates

A

No fatal toxic syndrome

29
Q

Biological meaning

A

Derived from biological source using biotechnology

30
Q

Bio similar meaning

A

Similar to existing originator biological medicine active substance is similar and clinically equivalent

31
Q

What is a pharmacodynamic interaction

A

Similar pharmacological effect
Antagonistic pharmacological effect

32
Q

Pharmacokinetics interaction

A

Adme
Absorption distribution metabolism excretion
Reduced

Pharma2023 (15 decks)

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