Prelimnary Flashcards
What do you do when there is impaired drug metabolism?
Reduce doors in several of impairment, reduce stores in elderly patients. There is a reduction in liver, volume, reduce metabolism of liposomal drugs, important for an hour therapeutic drugs.
Hyponatraemia
Reduce protein binding increase Friedrich, concentration of highly protein, bound drugs, toxicity
Reduced bile excretion
Fusidic acid rifampicin excreted in bile can accumulate
Hepatic encephalopathy
In severe, liver, disease drugs can impair cerebral function and can precipitate, a hepatic coma , such as constipating drugs are dating drugs, and drugs that cause hypokalaemia
How is hepatic encephalopathy treated?
Lactulose
Odema and ascites in liver disease can be exacerbated by
Drugs which cause fluid retention nsaid and corticosteroids
Enzyme inhibitors
Sickfaces.com
Sodium valproate
Isoniazid
Cimetidine
Ketoconazole
Flucanzole
Alcohol
Chlorphenicol
Erythromycin
Sulphonamide
Ciporfloxaxin
Omepraze
Metronidazole
Enzyme inducers
Barbiturates
St johns wort
Carbamazepine
RifMipicn
Alchol
Phenytoin
Griseofulvin
Phenobarbital
Sulfonyureas
Enzyme inhibitors =
Increased plasma concentration
Drugs which interact with grapefruit juice
Amiodarone ranoazine verapmail quetiapine sertaline taxrolimus ciclosporin colchine sildenfil
Which drugs should be stopped temporarily during any in the state which can result in dehydration
Damn
Diuretics
Ace inhibitors
Metformin
Nsaids
Breakthrough pain for immediate release morphine
1/6 to 1/10th of daily dose
Excess respiratory secretions for palliative care
Hyoscine or glycopyrru
Bowel colic in palliative care
Loperamide
Side effects ratio meaning
1 in 10 = very common
1 in 100 common
1 in 1000 uncommon
1 in 10,000 rare
1 in 10,000 very rare
Which drugs cause oral ulcers
Ace inhibitor
Nsaids
Nicrorandil
Methotrexate
Which drugs cause Oral candidiasis
Corticosteroids inhalers
Staining of teeth
Chlorhexidine iron tetracycline
Which drugs cause ostenocrosis of the jaw
Bisphosphantes
Which drugs cause ginivi hypertrophy
Ciclosporin nifedipine phenytoin
Which drugs cause Taste disurbances
Metformin ace inhibitor Amiodarone carbimazole claithryomycin metformin metronidazole zoplicone
Which two drugs do not chase myelosuppresipn
Vincristine and belomycin
Which drugs cause contact sensitisation
Methotrexate chlorpromazine cytotoxic drugs
Predisposing factors for QT prolongnation
Increase age female sex cardiac disease bradycardia electrolyte disturbance hypokalemia hypomangesia Hypocalcemia
