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Pharma2023 > Cns > Flashcards

Cns Flashcards

1
Q

Examples of H2 receptor antagonist

A

Cimetidine

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2
Q

Which of the following antipsychotics at the lowest risk of diabetes?

A

Haloperidol

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3
Q

What treatment do use to mild to moderate Alzheimer’s disease?

A

Donepezil galantamine or rivastigmine

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4
Q

What is the treatment for Madre Alzheimer’s disease?

A

Memantine is the drug of choice in patients with severe Alzheimer’s disease

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5
Q

Parkinson disease, dementia treatment

A

ACH inhibitors donepezil and galantMine
Rivastigmine was the only treatment with the UK marketing authorisation donepezil, galantmine and rivastigmine mean patches off level

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6
Q

When would you consider memantine in Parkinson’s disease dementia

A

When cholineterase are not tolerated

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7
Q

Management of drooling, saliva in people with Parkinson’s disease

A

Glycopyrronium

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8
Q

Entacopone can you clear your urine what colour?

A

Red brown

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9
Q

Can pizotefin cause weight
Increase

A

Yes

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10
Q

Tamoxifen and fluoxetine

A

Fluoxetine is predicted to decrease the efficacy of Tamoxifen. Avoid severe.

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11
Q

Which anti-sickness medication is most appropriate to treat post-operative, nausea and vomiting for Parkinson patient

A

Cyclizine

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12
Q

Pizotifen idnicated

A

, prophylaxis of migraine

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13
Q

Which medicine is licensed as a twice daily dose by mouth for moderate dementia associated with Parkinson disease 

A

Rivastigmine is the only licensed ACH inhibitor used for moderate dementia associated with Parkinson disease. The other ACH inhibitors are unlicensed.

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14
Q

What is interaction between propanolol and amirodone

A

Amirodone is predicted to increase the risk of cardiovascular side-effects, when given with propanolol

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15
Q

Interaction between methadone and fludrocortisone

A

Severe interaction fludrocortisone and methadone is predicted to increase the risk of tosade de points

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16
Q

Focal seizures treatment

A

Carbamazepine and Lamotrigine

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17
Q

Find it on in plasma concentration range

A

Neonate to 3 months, 6 to 15 mg/L, (25-60 micromol/litre) chilc three months to 18 years 10-20mg/L

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18
Q

Lithium and venlaxfine

A

Risk of serotonin syndrome

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19
Q

Examples of dopamine receptor agonist

A

Apomorphine bromcriptine cabergoline

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20
Q

What is dementia?

A

Cause when the brain is damaged by diseases, such as Alzheimer’s drugs or Parkinson

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21
Q

Name 3 Ach inhibitors

A

Donepezil -nms
Galantamine -sjs-
Rivastigmine- can chase GI disturbance

22
Q

Cholingeric side effects

A

Diarrhoea, urination, muscle, weakness, bronchospasm, bradycardia, vomiting, teary, eyes, salvation

23
Q

When do you use antipsychotics and dementia?

A

When it is severe risk of increased risk of stroke and death

24
Q

Tonic clonic seizures

A

Sodium valproate Lomtragine carbamazepine

25
Q

Absence seizures

A

Ethosuximide or valproate

26
Q

Myoclonic a tonic clonic

A

Valproate

27
Q

When can you drive a car in epilepsy

A

Seizure free for one year established pattern were no influence or unconsciousness. No history of unprovoked, seizures, seizures, due to change or withdrawal.

28
Q

Policy for seizure while asleep

A

Can drive if history of history of no wake seizures from one year from 1st to sleep, seizure establish pattern of sleep stages for three years of previous awake seizure

29
Q

Which drugs do you monitor foetal growth?

A

Topirmate / levetiracetam

30
Q

What is vigabatrin
Associated with

A

Encephalopathic symptoms mark sedation confusion

31
Q

Why is it important to remember about for phenytoin monitoring plasma

A

Small changes in dose missed doses change in drug absorption nonlinear relationship between dose on concentration. Phenytoin is highly protein bound drug when the protein binding is reduce monitor the plasma free concentration

32
Q

What can carbamazepine exacerbate

A

Atonic clonic and myoclonic seizures

33
Q

What do pharmacist I need to do every time you dispense valproate?

A

Patient card remind risk of pregnancy remind of need for annual specialist review dispense asshole packs whenever possible patient guide

34
Q

Name, the two short acting benzodiazepine

A

Lorazepam oxazepam

35
Q

How long does busiprone take to work

A

2 weeks

36
Q

How to withdraw benzodiazepines

A

Gradually convert over one week to equivalent diazepam dose, reduce diazepam dose by wanted to MG increments every 2 to 4 weeks

37
Q

Atomextine side effect

A

Suicidal ideation, liver toxicity, QT prolongation

38
Q

What is a contra indication in bipolar disease?

A

Do not give antidepressants in rapid cycling bipolar disorder. Recent history of hypo mania, manic episode.

39
Q

When would you think an antidepressant is it in effective?

A

Wait, four weeks, six weeks in the elderly

40
Q

How long to continue antidepressants

A

Continue for at least six months 12 months in the elderly 12 months in generalised anxiety disorder, two years in recurrent depression

41
Q

How to switch between antidepressants

A

Wait two weeks before - MAOI (moobemide does not require washout period )
switching with one week before -SSRI
(5 weeks for fluxteine 2 weeks if sertaline
switching with one to 2 weeks before switching - TCA -3 weeks if imipramine or clomipramine

42
Q

Which drugs has the highest risk of withdrawal reaction?

A

Paroxetine and venlafaxine

43
Q

Interaction between trancypromine clomipramine with pseudoephedrine adrenaline noradrenaline

A

Hypertensive crisis

44
Q

Patient counselling for
Moa

A

Avoid food containing tyramine mature cheese, wine eat only Fresh Food, the dangers of food and drug interactions exist two weeks after stopping


45
Q

Four: the pain, when would you assess effectiveness?

A

Try for at least 8 to 10 weeks, if two or more doses are missed then re- assistant reinitiate by specialist

46
Q

What anti-sickness is used in palliative care

A

Haloperidol, levomeppromazine

47
Q

Anti-sickness in chemotherapy or post operative, nausea and vomiting

A

Granistron ondasteron palonosetron

48
Q

Anti emetic prevention

A

Driperidol dexamethasone phenothiazine

49
Q

5HT receptor antagonist interaction

A

Increased risk of torsade de pointes with hypokalemia - loop diuretics, corticosteroids
Increased risk of QT prolongnation - amirodaone claithrymycin quinine sumatriptan lithium
Serotonin syndrome - 5ht1 agonist - moa ssri

50
Q

Breakthrough dose

A

1-10
or 1/6th of the total daily dose

Pharma2023 (15 decks)

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