Endocrine Flashcards
What is nephrogenic diabetes?
The kidneys do not respond to ADH
What is cranial diabetes?
The hypothalamus does not make enough ADH
What is the side effect of desmopressin?
Hyponatraemia convulsions
If fluid restriction, does not correct hyponatraemia in syndrome of inappropriate antidiuretic hormone secretion, then what can you use?
Democycline, blocks, renal tubular effect of ADH,
tolvaotan
vasopressin antagonist
Avoid rapid correction of hyponatraemia causes, osmotic, demyelination of new run serious CNS effects
High mineralcorticosteroid activity means
Fluid retention
Glucortucoid side effects I
Diabetes, osteoporosis peptic, ulcers, dyspepsia
Muscle wasting
Psychiatric reactions, infections, adrenal, suppression, glucoma
Why is it important to steroids in the morning?
Single dose in the mooning suppressive action on cortisol secretion is the least in the morning 
What do you give gesstational diabetes in women intolerant of Metformin, and do not want insulin
Glibenclamide from 11 weeks gestation after organogenesis
When are insulin requirements increased?
Infections, stress, puberty and presidency
Insulin requirements decreased
Unicorn disorders, Addison is coeliac disease
The 4 R’s
Right insulin right dose, right time right route
What antagonises hypoglycaemic a effect of insulin
Corticosteroids oral contraceptive diuretics
Metformin, MOa
Decrease liver gluconeogenesis and increases peripheral use
Pioglitazone more of action
Reduces peripheral resistance only continue, if Hba wants to produce by 0.5% within six months.
Go to thousands, SGL2 inhibitors more action
Inhibit, sodium, glucose ” transporter in the renal proximal, tubule to reduce glucose reabsorption and increase urinary excretion