Endocrine Flashcards
What is nephrogenic diabetes?
The kidneys do not respond to ADH
What is cranial diabetes?
The hypothalamus does not make enough ADH
What is the side effect of desmopressin?
Hyponatraemia convulsions
If fluid restriction, does not correct hyponatraemia in syndrome of inappropriate antidiuretic hormone secretion, then what can you use?
Democycline, blocks, renal tubular effect of ADH,
tolvaotan
vasopressin antagonist
Avoid rapid correction of hyponatraemia causes, osmotic, demyelination of new run serious CNS effects
High mineralcorticosteroid activity means
Fluid retention
Glucortucoid side effects I
Diabetes, osteoporosis peptic, ulcers, dyspepsia
Muscle wasting
Psychiatric reactions, infections, adrenal, suppression, glucoma
Why is it important to steroids in the morning?
Single dose in the mooning suppressive action on cortisol secretion is the least in the morning 
What do you give gesstational diabetes in women intolerant of Metformin, and do not want insulin
Glibenclamide from 11 weeks gestation after organogenesis
When are insulin requirements increased?
Infections, stress, puberty and presidency
Insulin requirements decreased
Unicorn disorders, Addison is coeliac disease
The 4 R’s
Right insulin right dose, right time right route
What antagonises hypoglycaemic a effect of insulin
Corticosteroids oral contraceptive diuretics
Metformin, MOa
Decrease liver gluconeogenesis and increases peripheral use
Pioglitazone more of action
Reduces peripheral resistance only continue, if Hba wants to produce by 0.5% within six months.
Go to thousands, SGL2 inhibitors more action
Inhibit, sodium, glucose ” transporter in the renal proximal, tubule to reduce glucose reabsorption and increase urinary excretion
DPP for inhibitors mode of action
DPP for breakdown hormone in creating which is made by the court in response to food to increase into the situation and lower Glucagon secretion
GLP, one agonist mode of action
Binds to an activated GLP, one receptors to increase into integration, suppress GlucaGen situation and slows gastric emptying
Hypertension complications with & without complications
140/80, without complications with complication to 130/80
How to treat hypoglycaemia in community
10 to 20 g of glucose if necessary. Repeat after 10 to 15 minutes. Coca-Cola hundred to 200 mL, Lucozade energy original 55, 200 mL sugar lumps to 86 sugar, 2 to 4 teaspoons Ribena 19 miles to be diluted.
How is sulphonyurea hypoglycaemia treated?
Always in hospital as it can persist for hours
What is raloxifene used for?
Secondary prevention and treatment for vertigo factors in postmenopausal osteoporosis
What is teriparatide used for
Use for treatment of menopausal osteoporosis
Does linagliptin require dose adjustment in renal impairment
No
When is dapagliflozin contra indiacted
<60
Will pregnant women need to take more levothyroxine when they are pregnant?
Yes
Humilin I
Intermediate
Humilin , S
Rapid acting
Levemir
Long acting
What is ottos externa can be triggered by?
Pseudomonas aeruginosa
