Msk Flashcards
Leflunamide advice precautions
Effective contraception for two years after treatment for women, and three months after treatment for men
Methotrexate Mia
Anti folate for inhibits, the conversion of dihydrofolate to tetrahydrofolate needed to make purines and purimifines and chromatin, and therefore DNA prevent cellular application
Methotrexate prescription requirements
Doors and frequency and prescribe only one strength
How many missed doses for methotrexate that need referring
Three days or more take next schedule dose on the normal day
What is the dose for folic acid for methotrexate?
5MG once weekly on the day after methotrexate, 5MG daily, except on methotrexate day, one MG daily except methotrexate day
What is methotrexate counselling?
Weekly dose, avoid OTC annual flu vaccination, methotrexate, cause, immunosuppression, methotrexate treatment booklet
Blood dyscriasis report, muscle search fever, tiredness, bruising leading nausea, vomiting, jaundice
What is methotrexate excreted?
Renally
What is the antidote for methotrexate side-effects?
Folinic acid Rescue
Conception and pregnancy advice for methotrexate
Effective contraception during and three months, after for both men and women pregnant women should avoid handling cytotoxic drugs
Interactions with methotrexate maim
Increased risk of blood disorders, Phenytoin trimethoprim clonazpine
reduced, renal excretion NSAIDs
Risk of hepatotoxicity istretoinin rifampicin
What is gout?
Condition which causes severe swelling, redness in the joints , caused by an accumulation of uric acid crystals form in the joint
Which drugs cause hyperuricaemia
Diuretics ciclosporin cytotoxic cancer tacrolimus
How long should, nsaid colchine be continued for
For one month after hyperuricaemia has been collected
What do you do to the dose of mercaptopurine or azathiopurine with allopurinol
Reduce to 1/4 to 1/2
Monitoring for quinine
Treatment every three months to assist further need may take up to 4 weeks for improvement
