Pregnancy Loss and Parturition Flashcards
What four things contribute to an increased chance of prenatal loss?
- Nutritional stress.
- Diseases of the reproductive tract (STD or STI) or those that affect the reproductive tract.
- Endocrine imbalances.
- Aging of the gametes prior to fertilization.
What are the three parts of nutritional stress?
- Energy shortage (The order of priority is: Maintenance, growth, reproduction).
- Mineral imbalances (Too high or too low).
- Vitamin deficiencies.
What does the aging of the gamete refer to?
How long it has been since the gamete was ejaculated or ovulated.
What three things cause the fetal adrenal glands to change size?
- Lack of space in the uterus.
- Lack of gas exchange.
- Lack of nutrients.
*All cause the fetus stress.
What hormone in the fetus’s body increases at parturition?
Fetal cortisol.
What is CRH?
Corticotropin-releasing hormone.
What is ACTH?
Adrenocorticotropin hormone.
What are the steps of parturition from fetal distress to the release of fetal corticosteroids?
- Fetal nutrition demands and placental insufficiency lead to stress.
- The hypothalamus releases CRH.
- CRH stimulates the anterior pituitary gland to release ACTH.
- ACTH stimulates the adrenal cortex.
- The adrenal cortex releases fetal corticosteroids (cortisol).
How does cortisol affect the lungs?
It causes surfactant production.
What does surfactant do in the lungs?
Prevent the alveoli from collapsing during breathing.
How does cortisol affect the liver?
It causes the liver to start storing glycogen for energy.
How does cortisol affect the thyroid?
It causes thyroid hormones to be released that stimulate the metabolism.
What happens to P4, E2, and PGF2a when cortisol reaches the placentome?
- P4 decreases.
- E2 increases.
- PGF2a increases.
What does the increase in E2 cause?
- Increased gap junctions in the myometrium.
- Increased number of OT receptors in the myometrium.
- The degradation of the CL.
- Cervical ripening.
What does the increase in PGF2a cause?
- CL degradation.
What does the degradation of the CL cause?
- The release of relaxin (RXL), which contributes to cervical ripening.
- The release of OT, which causes the uterine endometrium to produce PGF2a.
What happens when an increased number of gap junctions is combined with an increased amount of PGF2a from the uterine endometrium?
Organized “practice” contractions by the uterus.
What does cervical ripening refer to?
The opening and thinning of the cervix due to collagen breakdown.