Pregnancy & Childhood Viral Infections

Question 1

Describe Measles

Answer 1

• family Paramyxoviridae
• genus morbillivirus
  (-)ssRNA, helical, enveloped
• respiratory illness - high fever, cough, conjunctivitis, Koplik’s spots, maculopapular rash
• complications in 30%

Question 2

What’s the incidence rate of severe complications in pneumonia, measles & encephalomyelitis ?

Answer 2

• pneumonia = 1/20 cases
• acute measles encephalitis = 1/1000 cases
• acute disseminated encephalomyelitis = 0.4/100,000 cases

Question 3

Describe mumps

Answer 3

• family = Paramyxoviridae, genus= rubulavirus
  (-)ssRNA, helical, enveloped
• fever, headache, vomiting, muscle pain, swollen parotid glands
• meningitis 5-10%

Question 4

Describe Rubella

Answer 4

• family = Togaviridae, genus = rubivirus
  (+)ssRNA, icosahedral, enveloped
• flu-like illness, morbiliform rash, low grade fever, joint pains, headache
• Forchheimer’s sign (red bumps)

Question 5

What are some severe complications of rubella ?

Answer 5

• pneumonia
• meningitis
• ADEM
• congenital rubella syndrome

Question 6

What does ADEM stand for?

Answer 6

Acute Disseminated Encephalomylitis

Question 7

Describe Parvovirus B19

Answer 7

• family = Parvoviridae, genus= erythroparvovirus, species = primate erythroparvovirus 1
• ssDNA, icosahedral, non-enveloped
• papular purpic gloves & socks
• fifth disease (slap cheek)