Acute Inflammation Flashcards
1
Q
Describe the Innate Immune system
A
- immediate response to barrier breach
- non-specific, inborn recognition
- no memory
- interacts with & potentiated adaptive immune response
2
Q
What are some barriers to infection ?
A
- skin
- lysozyme in tears & other secretions
- stomach acid
3
Q
What are some components of the innate immune system ?
A
- recognition molecules
- cells
- soluble components
4
Q
What are some recognition molecules involved in the innate immune system ?
A
- collectins
- mannan binding lectins
- ficolins
- C-reactive proteins
5
Q
What are some cells that are involved in the innate immune system ?
A
- neutrophils
- mononuclear cells
- natural killer cells
- eosinophils
6
Q
What are some examples of soluble components of the innate immune system ?
A
- complement
- interferons
7
Q
What happens when normal barriers are breached?
A
- cells of the innate immune system use recognition molecules
- outcomes of this are pathogen destruction, phagocyte activation & inflammation
8
Q
Describe inflammation
A
- local response of living mammalian tissue to injury from an agent which could be;
- microbial
- immunological
- physical
- chemical
9
Q
What are the 5 cardinal signs of acute inflammation?
A
- redness
- heat
- swelling
- pain
- loss function
10
Q
What are the 2 types of inflammation ?
A
- acute & chronic
11
Q
Describe Acute inflammation
A
- divided into 2 events - vascular & cellular
- these 2 events are followed intermittently by the release of mediators
12
Q
Describe the vascular events
A
- initial transient vasoconstriction of arterioles
- persistent progressive vasodilation
- election of local hydrostatic pressure
- increase in vascular permeability
- transudation of fluid into extracellular space
- slowing/stasis of microcirculation
- leucocyte margination
13
Q
Describe Cellular Events
A
- margination
- rolling
- diapedesis
- chemotaxis
14
Q
Describe Margination
A
- Leukocytes assume the peripheral portion of the lumen
15
Q
Describe Rolling
A
- rolling and adhesion means leukocytes tumble slowly along the endothelium
- they adhere transiently, detach & bind again
