Cell Migration & Re-circulation

Question 1

What are the 2 kinds of adhesion molecules ?

Answer 1

1. selectins
2. integrins

Question 2

What are some endothelial cell examples of selectins ?

Answer 2

• P selectin = stored in granules & released to surface on activation
• E selectin = synthesised & stimulated by TNFa, IL-1 & microbial products

Question 3

What is an example of a lymphocyte selectin ?

Answer 3

L selectin
- homes to lymph nodes
- high on naive cells & low on activated/memory cells
- neutrophil attachment to inflamed endothelium

Question 4

Describe Integrins

Answer 4

• heterodimeric proteins
• alpha & beta subunits
• inside-out & outside-in signalling
• important in metastatic cancer