Pregnancy and breast cancer GTG Flashcards
What is the lifetime risk of breast cancer?
1 in 9
What % of women with breast cancer are under 40 years
15%
How common is breast cancer in pregnancy?
1 in 3000
What is the 5 year survival if Dx <50 years
50% at 5 years
What % of women who have had breast cancer then become pregnancy?
10%
If breast lump found in pregnancy
Refer to breast specialist
USS, if mammogram needed can be performed with sheilding
USS guided Bx
What imaging can be used to assess for mets in pregnancy?
CXR
Liver USS
Not to perform CT
Can consider MRI
Can surgery be performed in pregnancy?
Surgical Tx including local lymph clearance can be performed in all trimesters
Avoid reconstruction until after pregnancy
Can radiotherapy be performed in pregnancy?
Contraindicated until delivery
Can systemic chemotherapies be given
Contraindicated in 1 st trimester but safe in 2nd
Advise anthracycine regiemes
Can tamoixfen be given in pregnancy
No
Can trastuzumab be given in pregnancy
No
When should birth be timed with last chemo?
2-3 weeks after
When can breast feeding commence after chemo?
After 14 dayss from last chemo
Can you breast feed whilst taking tamoxifen or trastuzumab?
No
For how long should tamoxifen be stopped before trying to conceive?
3 months
Is long term survival after breast cancer effect by pregnancy?
No but would not advise if metastatic disease
Generally how long to wait after treatment of breast cancer for conceiving?
2 years, because highest risk of recurrence
If previous BC what test should be performed in pregnancy?
ECHO
What is the risk of chemotherapy induced amenohorrhea
< 30yrs
36-40yrs
<30 <5%
36-40 50%
Does tamoxifen/ GnRh analogue/transtuzuman cause subfertility
No but can can menstrual irregularity
