Pregnancy Flashcards

1
Q

Describe the pattern of lutenizing hormone throughout the ovarian cycle

A

Peaks just before ovulation then sharply falls

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2
Q

What happens in stage one of the ovarian cycle?

A

Follicle grows and produces oestrodiol

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3
Q

What is stage two of the ovarian cycle?

A

Ovulation

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4
Q

What is stage three of the ovarian cycle?

A

Formation of corpus luteum

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5
Q

Which hormones do the corpus luteum produce?

A

Oestradiol and progesterone

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6
Q

In which stages are oestrogen found?

A

1 2 and 3

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7
Q

In which stages are progesterone found?

A

3 alone

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8
Q

What hormone, measurable in urine, does the fertilised ovum produce?

A

HCG

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9
Q

Which hormones do the placenta secrete?

A

Human placental lactogen
Placental progesterone
placental oestrogen

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10
Q

Which hormones can cause insulin resistance?

A

hPL

Progesterones

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11
Q

In which trimester is gestational diabetes most likely?

A

3rd

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12
Q

What complications can be present in GDM?

A

Macrosomia
Polyhydramnios
IU death

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13
Q

What complications may be present in the neonate?

A

If premature, respiratory distress
Hypoglycaemia
Hypocalcaemia

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14
Q

By how much is the risk of CNS defects increased due to GDM?

A

5x

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15
Q

Why does hypoglycaemia occur?

A

If mother producing too much insulin and foetus makes own insulin at 3 months then after birth, loses insulin supply.

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16
Q

What is the definition of macrosomia?

A

Heavier than 4kg/ 8 8oz

17
Q

What folic acid dosage is given to pre-conception women?

A

5mg

18
Q

What can be given for BP control?

A

Labetalol
Nifedipine
Methyldopa

19
Q

What are some side effects of labetalol?

A

Postural hypotension
Tiredness
Liver damage
difficulty in micturition

20
Q

What are some side effects of nifedipine?

A

GI disturbance
oedema
headache

21
Q

What are some side effects of methyl dopa?

A

Depression
Liver damage- routine LFTs in first 12 weeks
Drowsiness affecting driving
xerostomia

22
Q

What pre-meal blood sugar is ideal?

A

less than 5.5 - 6

23
Q

What is given during delivery?

A

IV insulin

IV dextrose

24
Q

Which one of the SU are appropriate for use in pregnancy?

A

Glibenclamide

25
Q

How is the resolution of gestational diabetes tested?

A

Glucose tolerance test (GTT)

26
Q

If a patient is already on thyroxine how much should this be increased by during pregnancy?

A

50%

27
Q

What effect can hyperemesis have on TFT?

A

Lowered TSH

High fT4

28
Q

How often should thyroid be checking during pregnancy in pre-existing hypothryoidism?

A

Every month for 20 weeks

29
Q

What are the risks with untreated hypothyroidism?

A

Pre-eclampsia, postpartum haemorrhage, abortion.

Neurological underdevelopment

30
Q

How can thyrotoxicosis occur in pregnancy?

A

Hyperemesis increases hCG which lowers TSH which results in high T4

31
Q

What is the treatment for thyrotoxicosis?

A

Should resolve by 20 weeks

32
Q

What are the risks involved with hyperthyroidism and pregnancy?

A

Infertility
Spontaneous abortion
Thyroid storm in labour

33
Q

What drugs can be given to settle hyperthryoidism?

A

Labetalol
PTU in 1st trimester
Carbimazole in 2/3rd trimester

34
Q

What is the risk with using PTU?

A

Liver toxicity

35
Q

What are the issues around using carbimazole?

A

Scalp abnormalities

GI abnormalities

36
Q

What are the issues with TRAb?

A

Can cross the placenta and cause neonatal transient hyperthryoidism

37
Q

When can the patient become hypothryoid, after pregnancy?

A

Around 3 months

38
Q

What symptom can appear with hypothyroidism?

A

Post natal depression

39
Q

What drug can you add if become hypothryoid?

A

Thyroxine