MODY Flashcards
What kind of genetic inheritance does MODY have?
Autosomal dominant
What kind of genetic inheritance does MODY have?
Autosomal dominant
Is MODY IDDM or NIDDM?
Non-insulin dependent
At what age is onset?
Less than 25
Which transcription factors are prominently modified in MODY?
HNFalpha (in majority)
In the minority of MODY cases, where is the mutation?
Glucokinase
What is the onset of MODY in glucokinase mutated MODY?
At birth.
How is glucokinase mutated MODY managed?
Diet treatment
How is transcription factor mutated MODY managed?
1/3 diet, 1/3 OHA, 1/3 insulin
What class of drug, other than insulin, is used to treat HNFa MODY?
Sulphonylureas
Give an example of an SU
Gliclazide
Is MODY IDDM or NIDDM?
Non-insulin dependent
At what age is onset?
Which transcription factors are prominently modified in MODY?
HNFalpha (in majority)
In the minority of MODY cases, where is the mutation?
Glucokinase
