Practice Q's Flashcards
Which of the following modes of cell-cell communications has the shortest signal duration?
A: Autocrine
B: Paracrine
C: Juxtacrine
D: Endocrine
E: Neuronal
E: Neuronal
The inhibition of the first step of steroid synthesis by a drug will decrease the levels o fall steroid hormones. Which of the following enzymes catalyzes this step?
A: 21B-hydroxylase
B: 17,20-lyase
C. 17a-hydroxylase
D. P450scc
D - P450scc
Select the structure of cortisol
Double bond O on the left, 3 O’s on right
Select the structure of testosterone
Double bond O on left, OH on tip of pentagon
Which enzymes catalyzes the step?
A. P450scc
B. 17,20-lyase
C. 17a-hydroxylase
D. 21B-hydroxylase
C. 17a-hydroxylase
Which of the following is NOT an indication for antiandrogens?:
A. Endometriosis
B. Excessive Sexual drive in men
C. Benign prostate hyperplasia
D. Prostatic carcinoma
A. Endometriosis
Which of the following is NOT a physiologic effect of testosterone?:
A. Increase in HDL level
B. Increase in lean body mass
C. Deepening of the voice
D. Growth of beard hair
E. Stimulation of erythrocyte production
A. Increase in HDL levels
Which of the following is NOT an adverse effect of androgens in women?
A. Amenorrhea
B. Gynecomastia
C. Acne
D. Hirsutism
B: Gynecomastia
Select an INCORRECT pair of a drug and its property:
A. Spironolactone: anabolic steroid
B. Methyltestosterone: orally active androgen
C. Flutamide: non-steroidal antiandrogen
D. Finasteride: 5a-reductase inhibitor
E. Testosterone cypionate: androgen for IM injection
A: Spironolactone: anabolic steroid
Which of the following enzymes converts testosterone to a more potent androgen in the target tissues?:
A. Aromatase
B. 17a-hydroxylase
C. 5a-reductase
D. 21-hydroxylase
5a-reductase
What is the effect of the 17a-ethinyl group on the property of this drug?
A. Decrease in oral bioavailability
B. Gaining of antiestrogenic activity
C. Gaining of SERM activity
D. Prevention of the conversion to estrone
D. Prevention of the conversion to estrone
Which of the following statements is INCORRECT regarding the menstrual cycle?:
A. If pregnancy does not occur, production of estrogen and progesterone by corpus luteum declines
B. In the late follicular phase, estrogen stimulates the surge of LH and FSH
C. In the luteal phase, both estrogen and progesterone stimulate the production of LH and FSH
D. In the early follicular phase, estrogen suppresses the production of FSH
C. In the luteal phase, both estrogen and progesterone stimulate the production of LH and FSH
Which of the following is NOT a physiological effect of estrogens?:
A. Enhancement of the coagulability of blood
B. Increase in the rate of resorption of bone
C. Stromal development and ductal growth in the breast
D. Development of endometrial lining during menstrual cycles
B. Increase in the rate of resorption of bone
Which of the following estrogens can be used for depot injection due to its slow absorption?:
A. Estradiol valerate
B. Ethynyl estradiol
C. Mestranol
D. Quinestrol
A. Estradiol valerate
Which of the following is NOT a side effect of estrogens:
A. Endometrial carcinoma
B. Hot flashes
C. Breast cancer
D. Uterine bleeding
B. Hot Flashes
** - is a selective estrogen receptor modulator (SERM) used to treat breast cancer**
A. Tamoxifen
B. Diethyl stilbestrol
C. Clomiphen
D. Ethynyl estradiol
A. Tamoxifen
Which of the following is a conjugated estrogen existing in the mix of estrogens in Premarin?:
A. Equilin sulfate
B. Metranol
C. Ethynyl estradiol
D. Estradiol cypionate
A. Equilin sulfate
Which of the following SERMs is used to stimulate ovulation:
A. Toremifene
B. Tamoxifen
C. Clomiphene
D. Raloxifene
C. Clomiphene
Which of the following is NOT an aromatase inhibitor?:
A. Anastrozole
B. Exemestane
C. Letrozole
D. Fulvestrant
D. Fulvestrant
Which of the following is an antiestrogen action of raloxifene?:
A. Increase the risk for blood clots
B. Decreases LDL levels in blood
C. Decreases the risk for breast cancer
D. Prevent osteoporosis in postmenopausal women
C. Decreases the risk of breast cancer