Ex. 3 - Asthma Drugs : LABA Flashcards

1
Q

LABA MOA

A

Increase cAMP - bronchial smooth muscle relaxation and inhibit hypersensitivity mediators from mast cells (histamine and leukotrienes)

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2
Q

LABAs

A

Aformoterol Tartrate (Brovana)
Formoterol (Perforomist)
Indacaterol (Arcapta Neohaler)
Olodaterol (Striverdi Respimat)
Selmeterol (Serevent)

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3
Q

Aformoterol Tartrate

A

LABA
Brand: Brovana
Dosage form: Nebulizer solution
15mcg/2mL

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4
Q

Aformoterol Tartrate
Dosing: 4-10, 5-11, Adult

A

Adult - COPD only

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5
Q

Formoterol

A

LABA
Brand: Perforomist
Dosage form:
Nebulizer solution
20mcg/2mL

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6
Q

Formoterol Dosing:

A

Adult - COPD only unless used in combo with ICS

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7
Q

Indacaterol

A

LABA
Brand: Arcapta Neohaler
Dosage form:
Neohaler
75mcg/capsule

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8
Q

Indacaterol Dosing:

A

Adult - COPD only

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9
Q

Olodaterol

A

LABA
Brand: Striverdi Respimat
Dosage form:
Respimat 2.5 mcg/inhalation

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10
Q

Olodaterol dosing:

A

Adult - COPD only

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11
Q

Salmeterol

A

LABA
Brand: Serevent
Dosage form:
Diskus (50 mcg/blister)

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12
Q

Salmeterol dosing:

A

Age 5-11
Adult

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13
Q

LABA adverse effects

A

AE: tachycardia, headache, tremor, hypokalemia

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14
Q

LABA Boxed warning
1:

A

for increased risk of asthma related
death for all monotherapy LABA use- should not be
used alone for asthma management

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15
Q

LABA boxed warning 2:

A

For increasing hospitalizations in pediatric and adolescent patients

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16
Q

LABA counseling:

A

Prolonged QT seen with intentional overdoses
* Not for acute symptoms
* May be helpful for exercise induce bronchospasm
* Formoterol and indacaterol capsules should not be
taken orally

17
Q

LABA Pediatric considerations

A

Most children <4 yo cannot provide sufficient inspiratory flow for adequate lung delivery with a DPI