Ex. 3 - Asthma Drugs : LABA Flashcards
LABA MOA
Increase cAMP - bronchial smooth muscle relaxation and inhibit hypersensitivity mediators from mast cells (histamine and leukotrienes)
LABAs
Aformoterol Tartrate (Brovana)
Formoterol (Perforomist)
Indacaterol (Arcapta Neohaler)
Olodaterol (Striverdi Respimat)
Selmeterol (Serevent)
Aformoterol Tartrate
LABA
Brand: Brovana
Dosage form: Nebulizer solution
15mcg/2mL
Aformoterol Tartrate
Dosing: 4-10, 5-11, Adult
Adult - COPD only
Formoterol
LABA
Brand: Perforomist
Dosage form:
Nebulizer solution
20mcg/2mL
Formoterol Dosing:
Adult - COPD only unless used in combo with ICS
Indacaterol
LABA
Brand: Arcapta Neohaler
Dosage form:
Neohaler
75mcg/capsule
Indacaterol Dosing:
Adult - COPD only
Olodaterol
LABA
Brand: Striverdi Respimat
Dosage form:
Respimat 2.5 mcg/inhalation
Olodaterol dosing:
Adult - COPD only
Salmeterol
LABA
Brand: Serevent
Dosage form:
Diskus (50 mcg/blister)
Salmeterol dosing:
Age 5-11
Adult
LABA adverse effects
AE: tachycardia, headache, tremor, hypokalemia
LABA Boxed warning
1:
for increased risk of asthma related
death for all monotherapy LABA use- should not be
used alone for asthma management
LABA boxed warning 2:
For increasing hospitalizations in pediatric and adolescent patients