Androgens Drugs Flashcards

1
Q

Synthetic

A

Methyltestosterone
Testosterone Cypionate
Testosterone Enanthate
(addition on the 17 carbon)

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2
Q

Methyltestosterone

A

Synthetic
More active orally (17 methyl group)
Cannot be broken down

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3
Q

Testosterone Cypionate

A

Synthetic
IM
More hydrophobic
Prodrug
activated slowly in body
Prolonged absorption time

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4
Q

Testosterone enanthate

A

Synthetic
IM
More hydrophobic
Prodrug
activated slowly in body
Prolonged absorption time

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5
Q

5a-Reductase inhibitors

A

Finasteride
Dutasteride
(Add cross on top of addition of 17 carbon)

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6
Q

5a-Reductase inhibitors MOA

A

Block the conversion from testosterone to 5a-dihydrotestosterone

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7
Q

Finasteride

A

5a-Reductase inhibitor
TX: Benign prostatic hyperplasia
Male pattern baldness
Hirsutism in women

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8
Q

Dutasteride

A

5a-Reductase inhibitor
Tx: Benign prostatic hyperplasia
Male pattern baldness

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9
Q

Androgen receptor antagonists MOA:

A

Block the binding of endogenous androgens to the receptor or inhibit the activation of the receptors

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9
Q

Steroidal androgen receptor antagonists:

A

Cyproterone acetate
Spironolactone
(Additions at C 6-7)

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10
Q

Cyproterone acetate

A

Steroidal androgen
Tx: Hirsutism in women
Excessive sex drive in men

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11
Q

Spironolactone

A

Steroidal androgen
Tx: Hirsutism in women
Acne

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12
Q

Non-steroidal receptor antagonists:

A

Flutamide
Enzalutamide
(Looks nothing like testosterone; fully conjugated rings)

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13
Q

Flutamide

A

Non-steroidal receptor antagonist
Tx. Prostate cancer

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14
Q

Enzalutamide

A

Non-steroidal receptor antagonist
TX. of Metastatic castration resistant prostate cancer

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15
Q

Adverse effects: Men

A

Acne
Sleep apnea
Gynecomastia
Azoospermia and testicular atrophy
Increased aggressiveness and psychotic symptoms

16
Q

Adverse effects: Women

A

Hirsutism
Acne
Amenorrhea
Clitoral enlargement
Deepening of the voice