Poxviridae Flashcards
poxviridae meaning
pock-scar
Chordopoxvirinae genera (genuses)
Orthopox-, Parapox-, Avipox-, Capripox-, Leporipox-, Suipox-, Cervidpox-, Yatapox-, Molluscipoxvirus genus
poxviridae generas
Chordopoxvirinae and Entomopoxvirinae
Entomoxpoxvirinae genuses and A sp
insect poxviruses (A, B, C)
Morphology
linear dsDNA
complex capsid with lipids
Morphology variants
intracellular, non-enveloped virion, released by cell lysis
intracellular, enveloped (2 layers) virion, released by membrane fusion
penetrates to new cells by membrane fusion
form are infectious, attachment to different cell surface receptors
resistance
usually good
Chloroform inactivates all,
ether only capri-, para- and leporipoxviruses
Biological properties
mainly stenoxen
Orthopox, Parapox – zoonoses
embryonated eggs – CAM inoculation
Baltimore I
multiplies in the cytoplasm
infection is….
airborne, contact, arbo
cell proliferation
papule (cell proliferation) → pustule → scab → scar
Antigenic properties
strong antigens (except Parapox) – long immunity variolla=vaccinia
diagnosis
clinical signs
isolation – embryonated egg
EM (papulae)
Orthopoxvirus genus (name)
ortho=real
Orthopoxvirus genus (spp)
cowpox, buffalopox, camelpox, ectromelia, variola, vaccinia, monkeypox
Orthopoxvirus genus (A sp)
cattle buffalo camel mice human rodent monkey
Cowpox
Cowpox (cattle skin, teats)
rodents → cat → human
Buffalopox
buffalo skin
Camelpox
camel skin, eye, pneumonia
ectromelia
mice, skin – loose of legs, generalized