Polyomaviridae Flashcards

1
Q

polyoma meaning

A

poly-many

oma-tumour

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2
Q

morphology

A

circular dsDNA
icosahedral capsid
no envelope

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3
Q

Does it have an envelope?

A

NO

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4
Q

resistance

A
strong
56°C
 30 min
 pH 3
 lipid solvents
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5
Q

Bio properties

A

Baltimore I. – cellular transcriptase

oncogenic – SV40 model virus

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6
Q

Genus

A

Polyomavirus

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7
Q

….borne?

A

airborne

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8
Q

latency

A

integrates into genome-provirus

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9
Q

causes

A

persistent infection of the kidney-viruria

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10
Q

into cell cultures

A

microtumors

haemmaglutination

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11
Q

diagnosis

A

IF, EM, HAI

NA-hybridization, PCR

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12
Q

polyoma genus

A
Murine polyomavirus 
Simian polyomavirus SV40 
Bovine polyomavirus
Goose polyomavirus
Budgerigar fledgling disease virus
BK virus
JC virus
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13
Q

Murine polyoma (A sp.)

A

lab mice

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14
Q

Simian Polyoma (A sp.)

A

monkey-tumours, rondents

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15
Q

Goose Polyoma (dis)

A

nephritis

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16
Q

BK, JC virus (A sp.)

A

human

17
Q

BK virus (dis)

A

80-100% seropositivity
no clin symptoms or mild resp dis
nephropathy in kidney transplant patients

18
Q

JC virus (dis)

A

50-90% seroposivity
generally no clin signs
Progressive multifocal leucoencephalopathy