Poultry immunosuppressive diseases Flashcards
What are some immunosuppressive diseases?
*Infectious bursal disease virus
*Chicken anaemia virus
*Marek’s virus
*Reticuloendotheliosis virus
*Reovirus
*Haemorrhagic enteritis virus
*Mycotoxins
What are the different pathotypes of infectious bursal disease virus? IBDV +What do they cause?
*Mild strains = no clinical signs or mortality - causes bursal lesions
*Classical strain = mortality <20%, bursal lesion, moderate break through of MDA
*Very virulent strains = severe mortality >20%, bursal lesions + Break through high MDA levels
*Variant strains = <5%mortality, severe bursal lesions + immunosuppression
What are the effect of an IBDV infection?
*Destruction of B-cells
*Decrease in no. and function of plasma cells
*Decrease in antibody production
*Decreased immune response to vaccinations
*Increased susceptibility to other pathogenic + opportunistic agents
What are the signs of acute clinical IBD?
- Sudden onset
- Depression, ruffled feathers, vent pecking
- After 3 days of infection, mortality (normal % – 90+%)
and morbidity peaks and slows down by 5-7 days later - Mortality in layer-type tend to be higher than meat-type
- Dehydration
- Muscular haemorrhage
- Variable size and bursal lesion depending on disease
progress
What is seen with very virulent IBD (VVIBD)?
*Higher morbidity + mortality
*More prominent haemorrhage on muscle, proventriculus + bursa
*More severe lesions on bursa
What is seen with subclinical IBD?
*No mortality pattern
*Increased 2ary infection
*Lesions = bursal atrophy + associated with other secondary pathogens
How is IBDV diagnosed?
*Clinical signs
*Necropsy
*Histopathology
*Serology
What are differential diagnoses to IBDV?
- Coccidiosis
- Nephrogenic IBVs
- Newcastle disease
- Marek’s disease
- Adenoviruses
How is IBDV controlled?
*Biosecurity
*Management
*Vaccination
How is IBDV transmitted?
Horizontal transmission
What type of virus is Chicken anaemia virus?
DNA virus
What are different transmission routes of Chicken anaemia virus?
*Vertical
*Horizontal - faeco-oral
What organs does chicken anaemia virus affect? What does it cause?
*Thymus
*Spleen
*Bone marrow
-atrophy
-immunosuppression
-anaemia
What are clinical signs of chicken anaemia virus?
*anorexic
*Weak + depressed
*Pale
*Low PCV
*anaemic on blood smears
*Leukopenia / pancytopenia
What do chicken anaemia lesions look like? where are they found?
*Thymus = pale + atrophy
*Bursa of fabricous = small
*Bone marrow = pale / yellow