Postnatal Flashcards
Function of the placenta?
- fetal homeostasis
- gas exchange
- nutrient transport
- waste product transport
- acid base balance
- hormone production
- transport of IgG
What is contained within the umbilical cord?
- 3 blood vessels
- 1 x umbilical vein (oxygenated)
- 2 x umbilical artery (deoxygenated)
What are the 3 fetal shunts?
- ductus venosus
- foramen ovale
- ductus arteriosus
Explain ductus venosus?
- connection between the umbilical vein and inferior vena cava
- at the liver
- oxygenated
Explain foramen ovale
- right to left shunt in heart
- becomes the fossa ovalis
Why does blood avoid the lungs?
- lungs collapsed and fluid filled
- high resistance to flow
- only a small fraction of RV output goes via lungs
Within increasing gestation what do type 2 pneumocytes produce?
- they produce surfactant
- reduces resistance
What hormones prior to and during delivery slow fluid secretion and promote reabsorption?
- cortisol
- thyroid hormones
- catecholamines
Explain circulation changes postnatally?
- pulmonary vascular resistance drops
- systemic vascular resistance rises (prostaglandin drop, oxygen as a constrictor)
- ductus arterioles constricts
- foramen ovale closes
Remnant of the ductus arteriosus in an adult is called?
- liagmentum arteriosus
Symptoms of postnatal depression?
- tearfulness, irritability, anxiety, lack of enjoyment, poor sleep
- develops 2-6weeks post natally
Describe baby blues?
- common/normal
- develops within days postnatally
- brief period of emotional instability
- support and reasurrance
Explain puerperal psychosis?
- usually within 2 weeks postnatally
- sleep disturbances, confusion, mania, delusions
- treat as an emergency
Treatment of puerperal psychosis?
- admission
- antidepressants
- antipsychotics
- mood stabilisers
- ECT
Treatment of mild/moderate postnatal depression
- self help
- counselling
Treatment of moderate/severe postnatal depression
- psychotherapy
- antidepressants
- admission
First line antidepressant in pregnancy?
- SSRI
- Sertaline or fluoxetine
Risk of valproate and carbamazepine in pregnancy?
- highly teratogenic
- high risk of NTD
Lithium in pregnancy?
- avoid if possible
- known association with Ebstein’s anomaly (cardiac defects)
- do not use in breast feeding
Which antipsychotic should be avoided in pregnancy and why?
- clozapine
- risk of infant agranulocytosis
In utero glucose homeostasis?
- from placenta
- glycogen stores created in liver and muscle
Explain thermoregulation in utero?
- mum responsible
- during 3rd trimester brown fat laid down
Explain thermoregulation after delivery?
- heat produced by breakdown of stored fat
- peripheral vasoconstriction
Explain glucose homeostasis post delivery?
- drop in insulin
- increase in glucagon
- mobilisation of hepatic glycogen stores for gluconeogenesis
Primitive reflex involved in breast feeding?
- rooting and suck
Explain haematopoiesis prior and after birth?
- prior birth = liver
- post delivery = bone marrow
Explain physiological jaundice?
- breakdown of fetal haemoglobin
- immature conjugation pathways
- rise in circulating unconjugated bilirubin
Concern if high levels of unconjugated bilirubin cross the BBB?
- Kernicterus
Normal weight loss of baby in first few days?
- up to 10% of birth weight
Explain persistent pulmonary hypertension of the newborn?
- failure of the pulmonary circulation pressure to drop
- persistence of ductus arteriosus and foramen ovale
Treatment of persistent pulmonary hypertension of the newborn?
- ventilation
- nitric oxide (pulmonary vasodilator)
- sedation
Respiratory distress following c - section?
- transient tachypnoea of the newborn
- loss of hormonal stress influence
- fluid filled lungs