Polyomaviridae Flashcards
polyoma meaning
poly - many
oma - tumors
morphology
non-enveloped, icosahedral capsid, circular dsDNA
resistance
(naked)strong
replication
baltimore 1
replication in nucleus by cellular transcriptase
- integrates into chromosome of host cell
latency
yes, because integrates into genome -> provirus
which species are affected
lab mice monkey bovine goose humans
lab mice
murine polyomavirus in lab mice
monkey
simian polyomavirus SV40
goose polyomavirus
cause haemorhagic nephritis enteritis in geese
Humans
JK!
JC and BK
JC
no clinical symptoms
- cause progressive multifocal leucoencephalopathy (disease in brain white matter)
- rare fatal demyelization in immunosuppressed patients (AIDS)
BK
no clinical symptoms or mild resp. disease
- cause nephropathy in kidney transplant recipients
in cell cultures
microtumors
spread how
air borne
viruria
persistant infection in kidney - virus in urine
in blood
cause haemagglutination
antigenic properties
good antigens because they integrate into host genome making them able to hide from the immune system
budferigar fledging disease virus: species
bird polyomavirus, bad feathering, weaker induviduals
