Polyomaviridae Flashcards
1
Q
polyoma meaning
A
poly - many
oma - tumors
2
Q
morphology
A
non-enveloped, icosahedral capsid, circular dsDNA
3
Q
resistance
A
(naked)strong
4
Q
replication
A
baltimore 1
replication in nucleus by cellular transcriptase
- integrates into chromosome of host cell
5
Q
latency
A
yes, because integrates into genome -> provirus
6
Q
which species are affected
A
lab mice monkey bovine goose humans
7
Q
lab mice
A
murine polyomavirus in lab mice
8
Q
monkey
A
simian polyomavirus SV40
9
Q
goose polyomavirus
A
cause haemorhagic nephritis enteritis in geese
10
Q
Humans
A
JK!
JC and BK
11
Q
JC
A
no clinical symptoms
- cause progressive multifocal leucoencephalopathy (disease in brain white matter)
- rare fatal demyelization in immunosuppressed patients (AIDS)
12
Q
BK
A
no clinical symptoms or mild resp. disease
- cause nephropathy in kidney transplant recipients
13
Q
in cell cultures
A
microtumors
14
Q
spread how
A
air borne
15
Q
viruria
A
persistant infection in kidney - virus in urine
