6. Lecture

Question 1

eclipse

Answer 1

a period of time elapsed during which neither intracellular nor extracellular virus could be detected-

from the first mRNA until the first virion assembly
• parts:
• early transcription, translation: enzymes
• replication: nucleic acid multiplication
• late transcription, translation: structural proteins

Question 2

name the baltimore classification families (VI)

Answer 2

I. dsDNA
II. ssDNA
III. dsRNA
IV. +ssRNA
V. -ssRNA
VI. viruses using reverse transcriptase

Question 3

polycistronic

Answer 3

VIRUSES

a coding system viruses can have due to lack of space

Describing mRNA that encodes for multiple different polypeptides.

Question 4

monocistronic

Answer 4

CELLS

capacity of eukaryotes to code one gene per one mRNA

Question 5

ssDNA virus: primer

Answer 5

The DNA thread forms hairpins - self priming
•Cellular polymerase synthesizes complementary
thread

Question 6

describe the replication of ssDNA viruses

Answer 6

• small genome: no own polymerase
• cellular polymerase copies the dsDNA
• eventually one thread is removed

Question 7

•Autonomous ssDNA parvoviruses, Circoviridae:

Answer 7

•Multiplication only in S-phase (dividing) cells!
→ Pathology: enterocyte, embryo,
bone marrow cells…

Question 8

ssDNA Dependovirus

Answer 8

• use the replicase of adeno- or herpesviruses