PICLEC: MODULE 3 Flashcards
OFFICIAL ACIDS:
Treatment of gastric achlorhydria (lack of hcl)
DILUTED HYDROCHLORIC ACID
Arsenic chloride soution
ARSENIOUS ACID
“Nitromuriatic acid”, “aqua regia” — kingly water
NITROHYDROCHLORIC ACID
“Eau forte”, “Aqua fortis”— Strong water
NITRIC ACID
used for manufacturing explosives and nitrates. (act as preservative)
NITRIC ACID
OFFICIAL ACIDS
HYDROCHLORIC ACID
NITRIC ACID
PHOSPHORIC ACID
SULFURIC ACID
BORIC ACID
“Monsel’s solution”
FERROUS SUBSULFATE SOLUTION
the nitric acid converts the bismuth subnitrate to nitrate
BISMUTH MAGMA
Hydrochloric acid sub solutions
HYDROCHLORIC ACID
DILUTED HYDROCHLORIC ACID
ARSENIOUS ACID
NITROHYDROCHLORIC ACID
nitric acid sub solutions
FERROUS SUBSULFATE
MERCURIC NITRATE SOLUTION
BISMUTH MAGMA
Phosphoric acid sub solutions
PHOSPHORIC ACID USP (85-88% of H3PO4)
DILUTED PHOSPHORIC ACID (9.5-10.5 % of H3PO4)
Sulfuric acid sub solutions
SULFURIC ACID USP ( 94-95% H2SO4)
SACCHARATED FERROUS CARBONATE (diluted H2SO4)
Boric acid sub solutions
KAOLIN CATAPLASM
BORIC ACID SOLUTION
BORIC ACID OINTMENT
LISTER’S SOLUTION (antiseptic solution)
COMPOUN ZINC SULFATE POWDER (Antiseptic powder)
OFFICIAL BASES
SODIUM HYDROXIDE
POTASSIUM HYDROXIDE
CALCIUM HYDROXIDE
SODIUM CARBONATE
STRONG AMMONIA SOLUTION
DILUTED AMMONIA SOLUTION
Used as standard solution in acid-base titrations
SODIUM HYDROXIDE
Similar to NaOH, more deliquescent, stronger and more expensive
POTASSIUM HYDROXIDE
Mixture of compounds, resists pH changes upon addition of small quantities of acid or alkali
maintain pH of medicinals at optimal limits
BUFFERS
Used in formulation of opthalmic solutions
PHARMACEUTICAL BUFFERS
sodium phosphate + NaCl (pH 6-8)
“Phosphate buffered saline”
sorensen phosphate buffer
boric acid + sodium carbonate +KCL
GIFFORD’S BUFFER
Boric acid + sodium carbonate + NaCl
ATKIN’S AND PANTIN BUFFER
Boric acid + sodium BORATE + NaCl
FELDMAN’S BUFFER / PALITZSCH BUFFER
Raw material, inactive ingredients, medicinal vehicle, solvent
Water
Manufacture of pharmaceutical products, active pharmaceutical ingredients, APIs intermediates, compedial articles, and analytical Reagents as well as cleaning applications
Water
Varying amounts of suspended matter clay, sand, microorganisms, and fragments of plants and animals. Has distinct taste
Natural water, mineral water, Spring water, natural spring/water
Types of water hardness
Temporary and permanent hardness
Can be seen in shower heads; has soluble calcium and magnesium bicarbonates
Can be soften by boiling or lime process
Temporary hardness
Has calcium and magnesium chloride and sulfates
Permanent hardness
Produced on-site where they are used
bulk monographed water
Bulk monographed water
Purified water
Water for injection
Water for hemodialysis
Pure stream,
Excipient in the production of non parenteral prep in pharmaceutical app.
Not sterile
Purified water
Production of parenteral prep has endotoxin content must be controlled
Not sterile
Water for injection
For hemodialysis app.
Minimal Qual. Of source water = drinking water
WATER FOR HEMODIALYSIS
“Clean strem”
Pure stream
Porous load sterilization process, used to control humidity inside processing vessels
Minimal Qual of source water= drinking water
Pure stream
Sterile monigraphed water
Sterile purified water
Sterile water for injection
Bacteriostatic water for injection
Sterile water for irrigation
Sterile water for inhalation
Produced, packaged, and sterilized to preserve microbial quality throughout shelf life
Sterile monographed water
Purified water packaged an dredered sterile
Sterile purified water
Water for injection packaged and rendered sterile, SINGLE DOSE containers not more than 1L
sterile water for injection
Water for injection added one or more suitable antimicrobial preservatives, used as diluent In pre of parenteral prod. Multi dose container not more than 30mL
Bacteristatic water for injection
Water for injection, SINGLE DOSE container that may e LARGER then 1L and allow rapid delivery of contents
WTAER FOR IRRIGATION
Water for injection, used in inhalators and prep for inhalation sol’n
STERILE WATER FOR INHALATION
Nonmonographed water
Drinking water
Carbon dioxide free water
Distilled water
Deionized water
“Potable water”
DRINKING WATER
Prescribed source of feed water for prod. Of bulk monographed water pharmaceutical waters
DRINKING WATER
Purified water vigorously boiled for not less than 5 mins, cool and protected from absorption of atmospheric carbon dioxide
Carbon-dioxide free water
Vaporizing drinking water or higher quality of water and condensing into pure state
DISTILLED WATER
Produced by ion exchange process in which actions and anions are replaced with hydrogen and hydroxide
Deionized water
Inted to come direct contact with pharmaceutical products
GLASS CONTAINERS
Types of glass containers
Type I ( BOROSILICATE GLASS)
TYPE II ( TREATED SODA LIME SILICA
TYPE III (SODA LIME SILICA
Decreases coefficient in Pyrex glass
BORON
This glass is suitable for parenteral and non parenteral use
TYPE I (BOROSILICATE GLASS)
This glass is suitable for most acidic and neutral aqueous products for parenteral and nonparenteral
TYPE II ( TREATED SODA LIME SILICA)
This glass is not used for parenteral products or for powders for parenteral use
TYPE III (SODA LIME SILICA)
Used to differentiate type of glass
GLASS GRAINS TEST
Antioxidants solutions
Hypophosphorous acid
Sulfur dioxide
Sodium metabisulfite
Nitrogen gas
Argon gas
Reduce the oxidation of active substances and excipients in finished product
ANTIOXIDANTS
Powerful reducing agent (prevents oxidation from products)
Ferrous iodide syrup
HYPOPHOSPHOROUS ACID
Preservative in food, drugs and beverages
SULFUR DIOXIDE
Sulfur dioxide source
SODIUM METABISULFITE
Cod Liver oil and vitamin prep
Use to displace oxygen and moisture containing air in packaging material to extend shelf life
NITRIGEN GAS
Used as preservative
ARGON GAS
Increase refractive index
LEAD
Principal action in the intracellular fluid
POTASSIUM
Principal action in extracellular fluid
SODIUM
Principal ANION intracellular fluid
PHOSPHATE
Principal ANION extracellular fluid
CHLORIDE
2nd most abundant CATION in the ICF
MAGNESIUM
2nd most abundant CATION in the ECF
CALCIUM
2n most abundant in extracellular fluid
BICARBONATE
ELECTROLYTE REPLENISHERZ
SODIUM CHLORIDE
POTASSIUM CHLORIDE
CALCIUM CHLORIDE
Replenish the body’s electrolyte concentration the dehydration
ELECTROLYTE REOLENISHER
Systematic alkalizer
SODIUM BICARBONATE
POTASSIUM BICARBONATE
SODIUM CITRATE
POTASSIUM CITRATE
Normal physiological pH
7.35 - 7.45
Used to manage disorders associated with low pH
SYSTEMATIC ALKALIZER
Neutralize alkaline body fluid, particularly blood in patients who are suffering from systematic alkalosis
SYSTEMATIC ACIDIFIERS
Systematic alkalizer
SODIUM BIPHOSPHATE
CALCIUM CHLORIDE
AMMONIUM CHLORIDE
Form an integral part of one or more enzymes in a metabolic or biochemical process
ESSENTIAL AND TRACE ELEMENTS
Catakytic site of the enzymes and oxygen transporting proteins
IRON
COfactor of many enzymes in redox reactions
COPPER
Enhances the action of insulin and manages blood glucose concentration
ZINC
Essential role in development and maintenance of the immune system
ZINC
Antioxidant that protects cells from damage due to free radicals
MANGANESE
Required to potntate insulin for normal glucose metabolism
CHROMIUM
Moco is used by the enzymes to catalyze diverse redox reactions
MOLYDEMNUM
Antioxidant and protects against the actions of free radicals and carcinogenic factors
SELENIUM
Integral part of vitamin b12 (cyanocobalamin)
COBALT
Present in all peptides, proteins, and enzymes that contain cysteine and methionine amino acids
SULFUR
Integral component of thyroid hormones for cellular metabolism (thyroxin and triiodothyronine)
IODINE
Gastric antacids
MAGNESIUM ANTACIDS
ALUMINUM ANTACIDS
CALCIUM ANTACIDS
MISCELLANEOUS OFFICIAL ANTACIDS
Magnesium antacids
Common side effect of Magnesium is DIARRHEA
MAGNESIUM HYDROXIDES
MAGNESIUM CARBONATE
MAGNESIUM OXIDE
MAGNESIUM PHOSPHATE
MAGNESIUM TRISILICATE
ALUMINA AND MAGNESIA
Aluminum antacids
Side effects CONSTIPATION
ALUMINUM HYDROXIDE
ALUMINUM PHOSPHATE
DIHYDROXYALUMINUM SODIUM AMINO ACETATE
DYHYDROXYALUMINUM SODIUM CARBONATE
ALUMINA, MAGNESIA, AND CALCIUM CARBONATE
ALUMINA AND MAGNESIUM TRISILICATE
ALUMINA AND MAGNESIA
Calcium antacids
PRECIPITATED CALCIUM CARBONATE
CALCIUM CARBONATE ADN MAGNESIA
CLACIUM AND MAGNESIIUM CARBONATE
MAGALDRATEX ALUMINUM MAGNESIUM HYDROXIDE SULFATE
Miscellaneous official antacids
BISMUTH SUBCARBONATE
MILK OF BISMUTH
SODIUM BICARBONATE
POTASSIUM BICARBONATE
Defoaming agent, antiflatulence
SIMETHICONE
Protective and adsorbents
- symptom and not a disease
Impair digestion and or absorption
Increase bulk - stimulates peristalsis
Can lead to dehydration
Diarrhea