Phytonutrients and phytochemistry Flashcards
What are phytonutrients?
The plant makes chemicals in reaction to it’s environment.
What may phytochemicals be?
- medicines for the plant itself.
- protection from animal predation.
- communication between plants, animals and bacteria.
- chemicals produced as part of plant growth cycle.
How do phytonutrients work?
- function as antioxidants
- regulate the cell cycle
- increase detoxification of carinogenic compounds
- reduce DNA damage
- mimic or interact with hormones
Are all phytochemicals helpful? Why?
No. Some phytochemicals are dangerous or toxic to the body. E.g. many alkaloid class of phytochemicals are the basis for pharmaceutical drugs (morphine).
Phytates (found in beans, grains and legumes) can prevent the absorption of which minerals?
zinc
iron
calcium
Identify 4 differences in phytochemicals in plants.
- soil and water conditions
- humans and other animals around them
- climate
- bacteria, virus and pathogens
What can knowing the polarity and solubility help us find out about phytochemicals?
The best extraction methods for ingesting or preserving.
Phenols and polyphenols are also known as?
Phenolic compounds
What do the phenolic compounds include?
flavonoids
phenolic acids
lignans
tyrosol esters
What are the 6 major subgroups of flavonoids?
flavanols flavones flavonols flavanones anthocyanins isoflavonoids
What are flavonoids and carotenes together responsible for?
The colouring of fruits, vegetables and herbs.
What actions do flavonoids contain?
antioxidant anti-allergic anti-cancer anti-inflammatory anti-viral
What is epicatechin (flavonoid)?
A strong antioxidant, has insulin mimic action and improves heart health.
Name 2 health benefits of catechins.
reduce damage to the brain after a stroke (in mice)
enhances muscle fatigue resistance (in mice)
What are the health benefits of quercetin?
cancer (breast, colon, leaukaemia)
antioxidant and CVD prevention (reduced oxidised LDL)
athletes (improves lean body mass)
immune (inhibits histamine)
What is kaemferol?
A flavonoid. A yellow coloured powder and a strong antioxidant
Name two health benefits of kaemferol.
- Prevents arteriosclerosis by inhibiting the oxidation of LDL and formation of platelets in the blood.
- Chemopreventative agent - inhibits formation of cancer cells.
Name the flavonoid in grapefruit? What are the health benefits of grapefruit?
Naringin. antioxidant anti-carcinogenic cholesterol lowering activity reduces retinal disease linked to diabetes.
What are the contraindications of kaemferol?
Can interfere with certain drug metabolism including calcium channel blockers, sedatives, anti-depressants, warfarin, caffeine and oestrogen.
What is another name given to isolfavones and why?
Phytoestrogens because they have some oestrogen activity.
The richest food source of isoflavones is?
soybeans especially soy protein (tofu)
The biological effects of soy isofavones are strongly influenced by their metabolism which is strongly influenced by what?
Dependent on the activity of bacteria that colonize the human intestine.
Name 2 benefits of soy isoflavones and other phytoestrogens?
Oestrogenic effects in some tissues could help maintain bone density (osteoporosis)and improve blood lipid profiles (CVD).
Soy protein isolates prepared by ? tends to retain the isoflavones?
aqueous wash processes
What is the western equivalent of phytoestrogens instead of soy?
Lignans
Does flaxseed oil provide lignans?
No only the seed.
What are the health benefits of lignans (in particular flaxseed)?
might relieve constipation
lowers risk of lung cancer
slow proliferation of prostate epithelium
may lower blood glucose levels
What are proanthocyanidins?
Oligomeric flavonoids, mainly found in the skin of grapes. Gives it it’s red, blue, purple colours.
What are the health benefits of proanthocyanidins?
antioxidant
cardio protective effect
stabilise collagen and elastin (anti-aging)
anti-cancer
anti-allergic (inhibits enzymes that produce histamine)
High levels of anthocyanins are found in?
Acai, blackcurrent, blueberry, bilberry, cherry, red grape and purple corn.
What are anthocyanins protective against in plants?
UV radiation
What group does cyanidin belong to and where can you find them?
Anthocyanins.
In most red coloured berries and some other fruits.
What are some of the health benefits of cyanidin?
anticarcinogenic activity
vasprotective
anti-inflammatory
anti diabetes
What is the most studied stilbenoid?
Resveratrol
What are the health benefits of resveratrol?
heart health anti-aging (marketed use) anti-toxic may increase sperm count and testosterone levels in males antioxidant anti-cancer
How can red wine consumption help with CVD?
it contains resveratrol and even higher levels of flavonoids (compounds with anti-inflammatory and anti atherogenic properties).
Identify an interaction/safety concern with resveratrol.
High intake from supplements could increase the risk of bleeding when taking anticoagulant drugs such as warfarin.
What are phytosterols?
Plant derived lipids that are similar in structure and function to cholesterol.
What is the outcome of high intakes of plant sterols or stanols?
It can lower serum total and LDL cholesterol concentrations in humans.
What can sitosterols help induce?
Aptosis when added to cultured human prostate, brest and colon cancer cells.
How can sitosterols help benign prostatic hyperplasia patients?
Significantly improve urinary symptoms and increases maximum urinary flow
What are isothiocyanates?
Biologically active breakdown products of the sulphur rich glucosinolates.
What are the food sources of isothiocyanates?
cruciferous veg such as broccoli, cabbage, kale, bok choi, brussel sprouts, cauliflower, watercress
How can we increase the absorption of isothiocyanates?
By chewing raw cruciferous veg which increases the glucosinolate contact with myrosinase (enzyme that catalyses the hydrolysis of glucosinates).
How can isothiocyanates inhibit carcinogen activation?
CYP450 enzymes (cytochrome)
What is indole-3-carbinol (I3C)?
A compound derived by the enzymatic hydrolysis of a specific glucosinate known as glucobrassicin, which is first broken down into Di-Indole Methane (DIM).
Indole-3-carbinol induces which enzymes?
Phase 1 and 2.
Indole-3-carbinol induces CYP1A1 (phase 1 enzyme). What is this responsible for?
oestrogen metabolism, decreasing the availability of oestrogen metabolites that promote cancer growth.
Name two interactions/safety concerns with Indole-3-Carbinol.
skin rash
tremor
How are carotenoids absorbed?
Highly hydrophobic and absorbed via lipids.
What are the most common carotenoids in western diets (5)?
alpha carotene beta-carotene beta cryptoxanthin lutein zeaxanthin lycopene
Food sources of carotenoids
yellow, orange and red fruits and vegetable and green vegetables.
The conversion of pro vitamin A to vitamin A is dependent on what?
status of vitamin A in individual. It is inhibited when vit A stores are high.
Name two therapeutic benefits of a diet rich in carotenoids.
- can decrease the risk of ovarian cancer in postmenopausal women.
- reduces the risk of breast cancer in premenopausal women.
Name 3 food sources rich in beta carotene.
carrots
pumpkin seed
spinach
Why doesn’t high intake of beta carotene result in vitamin A toxicity? What can high doses cause?
Because the proportion converted to vitamin A decreases as beta-carotene intake increases.
Yellow or orange skin pigmentation.
Which 3 groups of people should not take beta-carotene supplements?
smokers
people consuming alcohol
people with a history of asbestos
What are the therapeutic effects of consuming high amounts of lutein in your diet?
reduced risk of developing Age Related Macular Degeneration (AMD).
reduce cancer risk reducing oxidative damage to DNA..
Which food sources are astaxanthins found?
algae
crustaceans
fish
What are the properties found in astaxanthins?
antioxidant anti-tumour anti-cancer anti-diabetic anti-inflammation
What is Lycopene?
Non vitamin A carotenoid, it is a fat soluble red pigment produced by plants.
What are the food sources of lycopene?
Mainly tomatoes Guava pink grapefruit watermelon papaya
What are the properties found in lycopene?
hypo-cholesterolemic cardio-protective anti-inflammatory anti-mutagenic anti-cancer
Which type of cancer may help with lycopene consumption and why?
prostate cancer, because the highest amount of lycopene is found in the testes. It reduces proliferation of prostatic epithelial cells.
How is lycopene best absorbed?
Processed and cooked sources rather than raw. Mixing with oils and fats increases bio-availability.
Limonene is classified chemically as?
monoterpene
What might limonene prevent and stimulate?
tumour cell proliferation
immune system
What symptoms might oral limonene cause?
nausea
vomiting
diarrhoea
What are punicalagins?
Tannins, large polyphenol compounds found in pomegranates.
Studies show that Pomegranate juice may slow down what?
progression of atherosclerosis.
Why might patients be asked to stop drinking/eat pomegranates?
Consumption of pomegranates for many years may cause swelling of the tongue or face.
What drug interaction does pomegranate juice have?
ACE inhibitor side effects