Physiology - Packman Flashcards
Mucous Neck Cells
produce mucous and bicarbonate
Parietal/Oxcytinc cells
produce HCL/gastric acid and intrinsic factor
Intrinsic factor
secreted from stomach and necessary for VIt B12 absorption
Enterochromaffin-like cells
produce histamines
Histamines
stimulate production of HCL/gastric acid, liberated by gastrin and PS system
Chief/zymogenic cells
produce pepsinogen/proteolytic enzyme and gastric lipase
Pepsinogen
produced as an inactive zymogen, activated in presence of HCL to become pepsin
D cells
produce hormone somatostatin
Somatostatin
secreted when acid is present in stomach, inhibits gastric acid secretion - how we control secretion of too much acid
G cells
produce gastrin, released by gastrin releasing factor
Gastrin
stimulates production of HCL, increases peristalsis, vasodilator; relaxes pyloric sphincter
Pyloric glands
globet cells, produce mucus and gastrin
Gastrin, histamine, ACH
stimulate HCL production
H2 receptor
on parietal cells, histamine binds to stimulate gastric secretion and HCL; H2 blockers - Zantac - inhibit HCL formation
Gastric Juice contains
HCL, Pepsin, AMylase, Gelatinase, Tribulyrase, Rennin - infants
Ghrelin
hormone released from mucosa of stomach, stimulates CNS -inc appetite, CCK increases satiety