Physiology of Pain (MC) Flashcards
Pain is classified by
disease, anatomy, general location, duration, intensity
Physiologic pain
nociception = potential tissue damage, NOT conscious
Pathologic pain = clinical pain
tissue damage
first pain fiber
Ag fiber (sharp and pricking)
second pain fiber
C fiber (burning, aching pain, signals inflamed tissues)
not activated by tissue-damaging event, activated by inflammation, very sensitive to mechanical stimulus
silent or sleepingimportant in the development of primary hyperalgesia
Transduction: inflammatory pain → ___
peripheral sensitization
where does transduction occur
at the site of injujry
increase of response to a noxious stimulus at injury
Primary hyperalgesia
pain response to non-noxious stimuli
Allodynia
repetitive stimuli leads to central sensitization
Modulation
Modulation leads to ______
increased excitability of peripheral neurons
an increase of response to a noxious stimulus adjacent to injury.
Secondary hyperalgesia
Modulation mediated by
mediated by dorsal horn neurons (CNS)-mediated by activation of the NMDA receptor
interacting with animal, observing animal
DIVAS = dynamic interactive visual analogic Scale