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Medicinal Chemistry > Physicochemical Properties Of Drugs > Flashcards

Physicochemical Properties Of Drugs Flashcards

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1
Q

What are the two types of antagonists ?

A

Competitive
Non-competitive

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2
Q

Explain the competitive antagonist

A
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3
Q

What does level of antagonism depend on

A

Strength of antagonist binding and concentration

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4
Q

What are type of non-competitive antagonists

A

Non-competitive
Umbrella effect

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5
Q

Explain the non-competitive antagonist

A
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6
Q

Explain the antagonist umbrella effect

A
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7
Q

Explain the irreversible antagonists

A
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8
Q

Explain tolerance and dependence

A
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9
Q

What is OMA

A
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10
Q

What are the most influential physicochemical properties of OMA

A
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11
Q

Solubility characteristics are of importance to

A
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12
Q

How does the drug reach general circulation

A
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13
Q

Explain the solubility of OMAs

A
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14
Q

What are the most important intermolecular attractive forces that are involved in the solubilization process

A
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15
Q

Explain dipole-dipole bonding

A
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16
Q

Explain hydrogen binding in terms of solubility

A
17
Q

Explain the ion-dipole bonding

A
18
Q

Explain the ion-ion bonding

A
19
Q

How to overcome problems with solubility

A
20
Q

How can we determine solubility

A

Partition coefficient

21
Q

What is the partition coefficient equation

A
22
Q

What does a higher partition coefficient value mean ?

A

Lipophilic

23
Q

How to mathematically estimate relative solubility

A
24
Q

Explain the acidity and basicity physicochemical property

A
25
Q

Explain acidity

A
26
Q

Explain the basicity

A
27
Q

Explain neutrals

A
28
Q

Give examples of neutrals

A

Ethers, ester, aldehyde, ketones

29
Q

Explain multifunctional molecules

A
30
Q

Explain ionization

A
31
Q

Explain ionization in zwitter ions

A
32
Q

Explain the ionization of a multiple functional molecule

A
33
Q

How to predict the degree of ionization of the molecule

A
34
Q

pH =pKa

A

The functional group 50% ionized and 50% unionized

35
Q

pH>pKa

A

Acidic groups are primarily ionized
Basic groups are primarily unionized

36
Q

pH<pKa

A

Acidic groups are primarily unionized
Basic groups are primarily ionized

Medicinal Chemistry (11 decks)

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