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Medicinal Chemistry > NSAIDs > Flashcards

NSAIDs Flashcards

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1
Q

Define pain

A
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2
Q

Define analgesia

A
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3
Q

What are the two types of analgesics

A

Narcotic
Non narcotic

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4
Q

Explain narcotic analgesics and give examples

A
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5
Q

Explain the non-narcotic analgesics and give example

A
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6
Q

What reduces pain without loss of consciousness

A

Analgesics

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7
Q

What are the kinds of pain.

A
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8
Q

Compare between Opioid analgesics and NSAIDs

A
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9
Q

Define inflammation

A
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10
Q

What does initial injury cause

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11
Q

Inflammation is characterized by what

A
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12
Q

What is the history of prostaglandins

A
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13
Q

Natural occurring PG are what

A

20C cyclopentano fatty acid

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14
Q

List the different PGs

A

PGE2
PGF2
PGI2
TXA4

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15
Q

What are the good PGs

A

PGE2
PGI2

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16
Q

Explain PGE2 functions

A
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17
Q

Explain PGF2 functions

A
18
Q

Explain PGI2 functions

A
19
Q

Explain TXA4 functions

A
20
Q

Explain COX1

A
21
Q

Explain COX 2

A
22
Q

Explain COX 3

A
23
Q

What is the effect of COX 1 inhibition

A

Gastric ulcers
Bleeding
Acute renal failure

24
Q

What are the effects of COX 2 inhibition

A

Reduce inflammation
Reduce pain
Reduce fever

25
Q

Why is the NSAIDs name misleading ?

A
26
Q

What are the similarities and differences between NSAIDs

A
27
Q

What are the common pharmacological effects of NSAIDs

A
28
Q

What is special about paracetamol ?

A

It’s only analgesics and antipyretic but not anti inflammatory

29
Q

What are the common adverse effects of NSAIDs

A
30
Q

What is the history of acetaminophen

A
31
Q

What is the adult oral dose

A
32
Q

What is the max dose of paracetamol

A
33
Q

When were first toxic effects discovered

A
34
Q

What is the mechanism of acetaminophen

A
35
Q

What are the trade names of paracetamol

A
36
Q

What is propacetamol

A

Prodrug from paracetamol

37
Q

How is propacetamol prepared

A
38
Q

What is the benefit of propacetamol over paracetamol

A

More water soluble
The onset analgesia is more rapid than paracetamol given orally

39
Q

What is the use of propacetamol

A
40
Q

Explain the plausible mechanism of acetaminophen

A
41
Q

Explain acetaminophen toxicity

A
42
Q

What is the antidote for acetaminophen toxicity

A

Medicinal Chemistry (11 decks)

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