Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

Medicinal Chemistry > Drug Metabolism -II > Flashcards

Drug Metabolism -II Flashcards

You may prefer our related Brainscape-certified flashcards:
Periodic Table flashcards Chemistry 101 flashcards AP® Chemistry flashcards Organic Chemistry 101 flashcards
1
Q

What is benzylic oxidation

A
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

What is epoxidation of alkenes

A
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Arene oxides are highly reactive for what two main reasons

A
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Are initially formed epoxides observed as metabolites ?

A
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Aliphatic oxidations in drugs having straight or branched alkyl chains can be categorized as what

A
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Aliphatic Hydroxylation gives what product

A

Alcohol

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

The carbon undergoing metabolism by aliphatic Hydroxylation must have what

A

At least one hydrogen attached

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

What is monoamine oxidase

A

It catalyses the oxidative deamination of amine to aldehyde

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

What are the two types of monoamine oxidases

A

MAO-A and MAO-B

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Which enzyme catalyses the oxidation of alcohols

A

Alcohol dehydrogenase

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Primary alcohols are oxidized to what

A

Aldehydes

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Secondary alcohols are oxidized to what

A

Ketones

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Tertiary alcohols are oxides to what

A

They cannot be oxidized

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Aldehydes are further oxidized to what

A

Aldehydes are highly reactive and undergo rapid metabolic oxidation to carboxylic acids

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Sulfur can be oxidized to form stable compounds by making what bonds

A
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

When is sulfur in its lowest oxidation state

A

When sulfur forms two bonds with other atoms

17
Q

Sulfides can be metabolically oxidized by what

A

The mixed function oxidase (MFOs) to sulfoxides and further oxidation to sulfones

18
Q

When is sulfur in its highest oxidation state ?

A
19
Q

Explain oxidation of amines

A
20
Q

Explain acetaminophen toxicity

A
21
Q

What is the antidote for acetaminophen toxicity

A
22
Q

Explain carbon heteroatom systems

A
23
Q

Explain dealkyltion

A
24
Q

Explain N-dealkylation in tertiary amines

A

Medicinal Chemistry (11 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions